Decoding Chromatin Goes High Tech

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Decoding Chromatin Goes High Tech Dan Levy, Or Gozani Cell Volume 142, Issue 6, Pages 844-846 (September 2010) DOI: 10.1016/j.cell.2010.08.032 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Readers Determine the Effects of Lysine Methylation The schematic depicts three different models for how methyllysine readers can sense and transduce histone methylation marks into biological outcomes. (A) A specific reader recognizes one mark and links it to one specific outcome. In this way, distinct readers link different marks to alternate functional outcomes. (B) Five distinct readers all specifically recognize the same mark, for example trimethylated histone H3 lysine 4 (H3K4me3), resulting in five alternate biological outputs being linked to the one mark. (C) One reader binds to multiple different marks (such as H3K9me3, H3K27me3, and H4K20me3), linking the three different marks to a single biological output. Cell 2010 142, 844-846DOI: (10.1016/j.cell.2010.08.032) Copyright © 2010 Elsevier Inc. Terms and Conditions