Volume 143, Issue 5, Pages e121S-e141S (May 2013)

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Volume 143, Issue 5, Pages e121S-e141S (May 2013) Clinical and Organizational Factors in the Initial Evaluation of Patients With Lung Cancer  David E. Ost, MD, MPH, FCCP, Sai-Ching Jim Yeung, MD, PhD, RPh, Lynn T. Tanoue, MD, FCCP, Michael K. Gould, MD, FCCP  CHEST  Volume 143, Issue 5, Pages e121S-e141S (May 2013) DOI: 10.1378/chest.12-2352 Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 1 [Introduction, Section 2.3] Overview of initial evaluation, diagnosis, staging, and treatment processes. There is significant overlap between cognitive processes. Developing a clinical diagnosis and assessment of the probable stage begins during the initial evaluation. This clinical assessment is subsequently refined on the basis of biopsy specimen findings that are part of formal staging and diagnosis. Similarly, information regarding the patient's functional status, comorbid conditions, and preferences may have an impact on treatment alternatives, and this in turn may have an impact on the type of diagnostic testing strategies chosen. CXR = chest radiograph. CHEST 2013 143, e121S-e141SDOI: (10.1378/chest.12-2352) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 2 [Introduction] Diagnostic algorithm for patients with suspected non-small cell lung cancer. The initial evaluation provides information on comorbidities, functional status, preferences, and probable extent of disease. The results of the initial evaluation determine the optimal site and sequencing of additional diagnostic and staging tests. Staging and diagnosis will be most efficient if the most advanced site of disease is targeted first. *When there is overwhelming imaging evidence of distant metastases, biopsy of the most accessible site is sufficient. DLCO = diffusing capacity of lung for carbon monoxide; EBUS-NA = endobronchial ultrasound-guided needle aspiration. CHEST 2013 143, e121S-e141SDOI: (10.1378/chest.12-2352) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 3 [Section 2.0] Range of frequencies of initial symptoms and signs of lung cancer. CHEST 2013 143, e121S-e141SDOI: (10.1378/chest.12-2352) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 4 [Section 2.4.1] Features of a standardized evaluation for systemic metastases. CHEST 2013 143, e121S-e141SDOI: (10.1378/chest.12-2352) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 5 [Section 3.0] Paraneoplastic syndromes in patients with lung cancer. CHEST 2013 143, e121S-e141SDOI: (10.1378/chest.12-2352) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 6 [Section 3.1.4] Food and medications to avoid during urine collection for 5-HIAA measurement. CHEST 2013 143, e121S-e141SDOI: (10.1378/chest.12-2352) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 7 [Section 3.2.1] Autoimmune paraneoplastic syndromes associated with lung cancer. CHEST 2013 143, e121S-e141SDOI: (10.1378/chest.12-2352) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 8 [Section 4.0] Time to treatment in US studies of timeliness of care in lung cancer. CHEST 2013 143, e121S-e141SDOI: (10.1378/chest.12-2352) Copyright © 2013 The American College of Chest Physicians Terms and Conditions