Volume 139, Issue 6, Pages (December 2010)

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Volume 139, Issue 6, Pages 1816-1819 (December 2010) Genetics and Environmental Interactions Shape the Intestinal Microbiome to Promote Inflammatory Bowel Disease Versus Mucosal Homeostasis R. Balfour Sartor Gastroenterology Volume 139, Issue 6, Pages 1816-1819 (December 2010) DOI: 10.1053/j.gastro.2010.10.036 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Genetic and environmental factors influence intestinal microbiota composition, which has an overall protective role in normal hosts, but contains an abnormal ratio of beneficial and aggressive bacterial species (dysbiosis) in Crohn's disease patients. This ratio of protective/ detrimental bacteria drives activated inflammatory cascades leading to Crohn's disease in genetically susceptible hosts and maintains mucosal homeostasis in normal subjects. Gastroenterology 2010 139, 1816-1819DOI: (10.1053/j.gastro.2010.10.036) Copyright © 2010 AGA Institute Terms and Conditions