Fast determination of antibiotics in whole blood

Slides:



Advertisements
Similar presentations
Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages
Advertisements

Laboratory diagnosis and biosafety issues of biological warfare agents
Vaccines for the elderly
C.-S. Lee, J.-H. Lee  Clinical Microbiology and Infection 
L. Boyanova  Clinical Microbiology and Infection 
High prevalence of azithromycin resistance to Treponema pallidum in geographically different areas in China  X.-S. Chen, Y.-P. Yin, W.-H. Wei, H.-C. Wang,
Benchmarking inappropriate empirical antibiotic treatment
Gut bacterial microbiota and obesity
Approach to diagnosis of infective endocarditis
S. Wagenpfeil, A. Neiss, K. Banz, P. Wutzler 
Herpes zoster in non-hospitalized children
Risk factors for cryptococcal infection among patients with rheumatoid arthritis receiving different immunosuppressive medications  T.-L. Liao, Y.-M.
Migrant health—a cause for concern?
Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010–2011): assessment of clinical practice.
C.-S. Lee, J.-H. Lee  Clinical Microbiology and Infection 
J.-P. Van geertruyden  Clinical Microbiology and Infection 
R. Cantón  Clinical Microbiology and Infection 
P. Nordmann, L. Poirel  Clinical Microbiology and Infection 
A.E. Muller, U. Theuretzbacher, J.W. Mouton 
Louis Pasteur, from crystals of life to vaccination
How to evaluate and predict the ecologic impact of antibiotics: the pharmaceutical industry view from research and development  R. Bax  Clinical Microbiology.
Non-antibiotic strategies for sepsis
Surveillance of Legionnaires’ disease in Austria
How to evaluate and predict the epidemiologic impact of antibiotic use in humans: the pharmacoepidemiologic approach  D. Guillemot  Clinical Microbiology.
Do clinicians consider the results of the BinaxNOW Streptococcus pneumoniae urinary antigen test when adapting antibiotic regimens for pneumonia patients? 
Impact of antibiotic restrictions: the pharmaceutical perspective
Vector control: a cornerstone in the malaria elimination campaign
Pharmacodynamics of doxycycline
C-3′Quaternary Ammonium Cephems, a New Wave of Cephalosporins
Training for the infectious diseases speciality in Norway
B. Gordts  Clinical Microbiology and Infection 
Laboratory diagnosis and biosafety issues of biological warfare agents
Early invasive fungal infections and colonization in patients with cirrhosis admitted to the intensive care unit  E. Theocharidou, B. Agarwal, G. Jeffrey,
Elements of design: the knowledge on which we build
Levofloxacin in the treatment of ventilator-associated pneumonia
G. Pappas  Clinical Microbiology and Infection 
Metagenomics and probiotics
Laboratory diagnosis of Clostridium difficile disease
Recent developments in staphylococcal scalded skin syndrome
The practice of travel medicine in Europe
T.M. File  Clinical Microbiology and Infection 
Systematic review of antibiotic consumption in acute care hospitals
Update on antifungal resistance in Aspergillus and Candida
Survival of hepatitis A and E viruses in soil samples
Abstracts cont. Clinical Microbiology and Infection
Pandemic lineages of extraintestinal pathogenic Escherichia coli
Benchmarking inappropriate empirical antibiotic treatment
Reducing antibiotic use in influenza: challenges and rewards
H. Leblebicioglu, C. Eroglu  Clinical Microbiology and Infection 
Vaccines for the elderly
Clinical infection services—the Leiden experience
Sequential time to positivity of blood cultures can be a predictor of prognosis of patients with persistent Staphylococcus aureus bacteraemia  M.-S. Hsu,
An after-hours clinical liaison blood culture service—is it worth it?
Statin use and clinical outcomes among pneumonia patients
Clinical Microbiology and Infection
Clinical Microbiology and Infection
K. Kaier, N.T. Mutters, U. Frank  Clinical Microbiology and Infection 
A. van Samkar, M. C. Brouwer, Y. Pannekoek, A. van der Ende, D
The atypical pneumonias: clinical diagnosis and importance
Facilitating learning and change in physicians: Implications for a system of continuing medical education in Europe  Robert D. Fox  Clinical Microbiology.
Abstracts Clinical Microbiology and Infection
Modelling during an emergency: the 2009 H1N1 influenza pandemic
J.L. Balcázar  Clinical Microbiology and Infection 
G.C. Schito  Clinical Microbiology and Infection 
The DUEL study: a multi-center in vitro evaluation of linezolid compared with other antibiotics in the Netherlands  J.W. Mouton, A.R. Jansz  Clinical.
Impact of antibiotic restrictions: the patient's perspective
Comparative study of pediculicidal effect of medical plants
Abstracts Clinical Microbiology and Infection
CMI readers' survey Clinical Microbiology and Infection
The future of diagnostic bacteriology
Presentation transcript:

Fast determination of antibiotics in whole blood Q. Chen, A. Andersson, M. Mecklenburg, B. Xie  Clinical Microbiology and Infection  Volume 19, Issue 9, Pages 869-874 (September 2013) DOI: 10.1111/1469-0691.12074 Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Schematic for the flow-injected Enzyme Thermistor instrument. Clinical Microbiology and Infection 2013 19, 869-874DOI: (10.1111/1469-0691.12074) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Penicillin G calibration curves at various buffer pH values. Clinical Microbiology and Infection 2013 19, 869-874DOI: (10.1111/1469-0691.12074) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 3 Calibration curves for the antibiotics determined in buffer (a) and in whole blood (b). Clinical Microbiology and Infection 2013 19, 869-874DOI: (10.1111/1469-0691.12074) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 4 Calibration curves for the penicillin G spiked samples. Clinical Microbiology and Infection 2013 19, 869-874DOI: (10.1111/1469-0691.12074) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 5 Repeatability study using antibiotic-spiked whole human blood: (a) actual chart recorder readout and (b) graph of the 0.68 mM penicillin G data set. Clinical Microbiology and Infection 2013 19, 869-874DOI: (10.1111/1469-0691.12074) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions