Epidermal Label-Retaining Cells: Background and Recent Applications

Slides:

Advertisements

Similar presentations

Ephrin-A2 and Ephrin-A5 Are Important for the Functional Development of Cutaneous Innervation in a Mouse Model Dulharie T. Wijeratne, Jennifer Rodger,

Advertisements

Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling Franziska Peters, Susanne Vorhagen, Susanne Brodesser, Kristin Jakobshagen,

Invasion of Herpes Simplex Virus Type 1 into Murine Epidermis: An Ex Vivo Infection Study Elena Rahn, Philipp Petermann, Katharina Thier, Wilhelm Bloch,

Activated Kras Alters Epidermal Homeostasis of Mouse Skin, Resulting in Redundant Skin and Defective Hair Cycling Anandaroop Mukhopadhyay, Suguna R.

C-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny Isabel Arnold, Fiona M Watt

Andrey A. Panteleyev, Pamela J. Mitchell, Ralf Paus, Angela M

Genes Involved in Stem Cell Fate Decisions and Commitment to Differentiation Play a Role in Skin Disease Kimberly A. Honeycutt, Maranke I. Koster, Dennis.

Kai Kretzschmar, Denny L. Cottle, Pawel J. Schweiger, Fiona M. Watt

Impaired Keratinocyte Proliferative and Clonogenic Potential in Transgenic Mice Overexpressing σ in the Epidermis Francesca Cianfarani, Silvia.

In Vivo Detection of Small Subsurface Melanomas in Athymic Mice Using Noninvasive Fiber Optic Confocal Imaging Peter Anikijenko, Liem T. Vo, Elise R.

Analysis of Hair Follicles in Mutant Laboratory Mice

Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Rebecca J. Morris, Carl D. Bortner, George.

GW Bodies: Cytoplasmic Compartments in Normal Human Skin

Epidermal Differentiation: Transgenic/Knockout Mouse Models Reveal Genes Involved in Stem Cell Fate Decisions and Commitment to Differentiation Maranke.

Volume 9, Issue 1, Pages (July 2005)

Raija Tammi Journal of Investigative Dermatology

Label-Retaining Cells (Presumptive Stem Cells) of Mice Vibrissae Do Not Express Gap Junction Protein Connexin 43 Maja Matic, Marcia Simon Journal of.

Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis

Fas and c-kit are Involved in the Control of Hair Follicle Melanocyte Apoptosis and Migration in Chemotherapy-Induced Hair Loss Andrei A. Sharov, Guang-Zhi.

Integrin β6-Deficient Mice Show Enhanced Keratinocyte Proliferation and Retarded Hair Follicle Regression after Depilation Yanshuang Xie, Kevin J. McElwee,

Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1 Shreya Bhattacharya, Heather.

Reduced Susceptibility to Two-Stage Skin Carcinogenesis in Mice with Epidermis- Specific Deletion of Cd151 Norman Sachs, Pablo Secades, Laura van Hulst,

Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells Tetsuro Kobayashi, Toshiroh Iwasaki,

Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle Jonathan.

Natalia V. Botchkareva, Vladimir A. Botchkarev, Barbara A. Gilchrest

R. Toll, U. Jacobi, H. Richter, J. Lademann, H. Schaefer, U

Hair Cycling and Wound Healing: To Pluck or Not to Pluck?

Slc1a3-CreER as a Targeting Tool for the K6+ Epithelial Stem Cell Niche and its Precursors during Mouse Hair Follicle Cycle Aiko Sada, Prachi Jain, Sherry.

Mutations in the Lipase H Gene Underlie Autosomal Recessive Woolly Hair/Hypotrichosis Yutaka Shimomura, Muhammad Wajid, Lynn Petukhova, Lawrence Shapiro,

Different Consequences of β1 Integrin Deletion in Neonatal and Adult Mouse Epidermis Reveal a Context-Dependent Role of Integrins in Regulating Proliferation,

The Cell Cycle Regulator Protein σ Is Essential for Hair Follicle Integrity and Epidermal Homeostasis Nigel L. Hammond, Denis J. Headon, Michael.

Francois le Pelletier, Anne Janin Journal of Investigative Dermatology

The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but not for Maintenance of the Epidermal Stem Cell Compartment Héctor G. Pálmer,

Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal–Epidermal Composites Rajesh L. Thangapazham, Peter Klover, Ji-an.

Integral Lipid in Human Hair Follicle

Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy Dmitry V. Chebotaev,

Thaned Kangsamaksin, Rebecca J. Morris

Epidermal Stem Cells do not Communicate Through Gap Junctions

Tuning Wnt Signals for More or Fewer Hairs

Trangenic Misexpression of the Differentiation-Specific Desmocollin Isoform 1 in Basal Keratinocytes Frank Henkler, Molly Strom, Kathleen Mathers, Hayley.

Epidermal Stem Cells in the Isthmus/Infundibulum Influence Hair Shaft Differentiation: Evidence from Targeted DLX3 Deletion Jin-Chul Kim, Olivier Duverger,

Ephrin-A2 and Ephrin-A5 Are Important for the Functional Development of Cutaneous Innervation in a Mouse Model Dulharie T. Wijeratne, Jennifer Rodger,

Andreya Sharov, Desmond J. Tobin, Tatyana Y

Distinct Roles for Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Controlling the Rate of Hair Follicle Morphogenesis Natalia V. Botchkareva,

UVB Irradiation Stimulates Deposition of New Elastic Fibers by Modified Epithelial Cells Surrounding the Hair Follicles and Sebaceous Glands in Mice

Murine Epidermal Label-Retaining Cells Isolated by Flow Cytometry do not Express the Stem Cell Markers CD34, Sca-1, or Flk-1 Michael R. Albert, Ruth-Ann.

Sharon Grehan, Charles Allan, Elizabeth Tse, David Walker, John M

Characterization of Quiescent Epithelial Cells in Mouse Meibomian Glands and Hair Follicle/Sebaceous Glands by Immunofluorescence Tomography Geraint.

Journal of Investigative Dermatology

Delineating Immune-Mediated Mechanisms Underlying Hair Follicle Destruction in the Mouse Mutant Defolliculated Fiona Ruge, Aikaterini Glavini, Awen M.

Rebecca M. Porter, Julia Reichelt, Declan P. Lunny, Thomas M. Magin, E

An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution Abigail K. Langton, Sarah E. Herrick,

Yoshiharu Kawaguchi Journal of Investigative Dermatology

Society for Investigative Dermatology 2010 Meeting Minutes

Multiple Epidermal Connexins are Expressed in Different Keratinocyte Subpopulations Including Connexin 31 Wei-Li Di, Elizabeth L. Rugg, Irene M. Leigh,

Distinct Roles for Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Controlling the Rate of Hair Follicle Morphogenesis Natalia V. Botchkareva,

54th Annual Montagna Symposium on the Biology of Skin

Research Snippets Journal of Investigative Dermatology

Gender Differences in Mouse Skin Morphology and Specific Effects of Sex Steroids and Dehydroepiandrosterone Lamia Azzi, Mohamed El-Alfy, Céline Martel,

Expression of Activated MEK1 in Differentiating Epidermal Cells Is Sufficient to Generate Hyperproliferative and Inflammatory Skin Lesions Robin M. Hobbs,

Intravital Multiphoton Imaging of Cutaneous Immune Responses

Urokinase is a Positive Regulator of Epidermal Proliferation In Vivo

Have Hair Follicle Stem Cells Shed Their Tranquil Image?

MHC Class I Expression in Murine Skin: Developmentally Controlled and Strikingly Restricted Intraepithelial Expression During Hair Follicle Morphogenesis.

On-Line Diffusion Profile of a Lipophilic Model Dye in Different Depths of a Hair Follicle in Human Scalp Skin Ylva Y. Grams, Lynne Whitehead, Gerda.

Journal of Investigative Dermatology

Conceptual Issues in Measuring the Burden of Skin Diseases

Yasushi Hanakawa, Hong Li, Chenyan Lin, John R

Liren Tang, Shabnam Madani, Harvey Lui, Jerry Shapiro

Journal of Investigative Dermatology

Presentation transcript:

Epidermal Label-Retaining Cells: Background and Recent Applications Kristin M. Braun, Fiona M. Watt Journal of Investigative Dermatology Symposium Proceedings Volume 9, Issue 3, Pages 196-201 (September 2004) DOI: 10.1111/j.1087-0024.2004.09313.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Schematic diagram showing the preparation of whole-mounts of mouse tail skin epidermis. The different epidermal compartments are indicated in the confocal micrograph. HS, hair shaft; IFE, interfollicular epidermis; SG, sebaceous gland; ORS, outer root sheath. Journal of Investigative Dermatology Symposium Proceedings 2004 9, 196-201DOI: (10.1111/j.1087-0024.2004.09313.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Visualization of label-retaining cells. Ten-day-old mice were injected with 50 mg BrdU per kg body weight every 12 h for a total of four injections. Mice were euthanized after a chase period of 70 d. (A) Section of mouse tail skin. (B) Whole-mount. Green fluorescence (A, B): LRC visualized with antibody to BrdU. Red fluorescence (B) anti-keratin 14 immunolabelling. HF, hair follicle; IFE, interfollicular epidermis; SG, sebaceous gland. Scale bars: 50 μm. Journal of Investigative Dermatology Symposium Proceedings 2004 9, 196-201DOI: (10.1111/j.1087-0024.2004.09313.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions