Figure 1 Neuromyelitis optica spectrum disorder (NMOSD) subgroups and patients with relapsing-remitting multiple sclerosis (RRMS) show different antibody.

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Figure 1 Neuromyelitis optica spectrum disorder (NMOSD) subgroups and patients with relapsing-remitting multiple sclerosis (RRMS) show different antibody signatures Neuromyelitis optica spectrum disorder (NMOSD) subgroups and patients with relapsing-remitting multiple sclerosis (RRMS) show different antibody signatures Heat maps (A: RRMS [blue] vs aquaporin-4 antibody [AQP4Ab]+ NMOSD [red]; B: RRMS [blue] vs AQP4Ab− NMOSD [purple]; C: AQP4Ab+ NMOSD [red] vs AQP4Ab− NMOSD [purple]). The top 20 peptides from all pairwise subgroup comparisons as well as all AQP4 peptides are shown as rows (see key for peptides). Patients from the different subgroups are shown as columns (see key for patient groups). The color (see key for z score) indicates the intensity of the peptides standardized to the healthy controls, with blue indicating an upregulation and red a downregulation of peptide reactivities, given in standard deviations. Heat maps show a clustering of RRMS and AQP4Ab+ NMOSD (A) as well as RRMS and AQP4Ab− NMOSD (B), suggesting different antibody signatures in these patient groups. In contrast, such a clustering is not evident comparing the 2 NMOSD subgroups (C). CMV = cytomegalovirus; EBV = Epstein-Barr virus; VZV = varicella-zoster virus. Imke Metz et al. Neurol Neuroimmunol Neuroinflamm 2016;3:e204 © 2016 American Academy of Neurology