Relaxin in cardiovascular and renal disease

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Relaxin in cardiovascular and renal disease C.S. Samuel, T.D. Hewitson Kidney International Volume 69, Issue 9, Pages 1498-1502 (May 2006) DOI: 10.1038/sj.ki.5000264 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Relaxin immunostaining in the rat kidney. Distribution of relaxin immunostaining at (a) low- and (b) high-power magnification, in the renal cortex of rats subjected to unilateral ureteric obstruction. Relaxin immunostaining was detected with the rabbit anti-rat serum 267-5 (kindly provided by Professor O David Sherwood, University of Illinois at Urbana Champaign, Urbana, IL, USA). (c) Also shown is the same kidney with non-immune serum. Bars show relative magnification. Kidney International 2006 69, 1498-1502DOI: (10.1038/sj.ki.5000264) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 (a) Relaxin decreases established cardiac and (b) renal fibrosis in relaxin-deficient mice. Collagen concentration (collagen content/dry weight (a)8 left ventricular or (b)6 kidney tissue) was determined from 12-month-old relaxin wild-type (RLX+/+), relaxin knockout (RLX-/-) mice (with established fibrosis) treated with vehicle alone or RLX-/- mice treated with 0.5 mg/kg/day H2 relaxin for a 14-day period. Numbers in parenthesis represent the number of animals used per group. *P<0.05 compared with respective values from RLX+/+ mice. †P<0.05 compared with respective values from RLX-/- mice treated with vehicle alone. Kidney International 2006 69, 1498-1502DOI: (10.1038/sj.ki.5000264) Copyright © 2006 International Society of Nephrology Terms and Conditions