Suspecting and Testing for Alpha-1 Antitrypsin Deficiency—An Allergist's and/or Immunologist's Perspective Timothy J. Craig, DO The Journal of Allergy.

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Presentation transcript:

Suspecting and Testing for Alpha-1 Antitrypsin Deficiency—An Allergist's and/or Immunologist's Perspective Timothy J. Craig, DO The Journal of Allergy and Clinical Immunology: In Practice Volume 3, Issue 4, Pages 506-511 (July 2015) DOI: 10.1016/j.jaip.2015.04.005 Copyright © 2015 The Authors Terms and Conditions

Figure 1 Relationships between AATD genotype, A1-PI serum level, and risk of developing emphysema.1,4,10-12 Depending on their genotype, AATD patients present with various A1-PI circulating levels and, therefore, are at different risks of developing emphysema. The dotted line denotes the historical A1-PI threshold level (11 μM) below which patients are at an increased risk of developing emphysema. AATD, Alpha-1 antitrypsin deficiency; A1-PI, alpha-1 proteinase inhibitor; N/D, not detectable. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 506-511DOI: (10.1016/j.jaip.2015.04.005) Copyright © 2015 The Authors Terms and Conditions