S-100 after correction of congenital heart defects in neonates: is it a reliable marker for cerebral damage? Michael A Erb, MD, Markus K Heinemann, MD,

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Presentation transcript:

S-100 after correction of congenital heart defects in neonates: is it a reliable marker for cerebral damage? Michael A Erb, MD, Markus K Heinemann, MD, Hans P Wendel, PhD, Leo Häberle, MD, Ludger Sieverding, MD, Christian P Speer, MD, Gerhard Ziemer, MD, PhD The Annals of Thoracic Surgery Volume 69, Issue 5, Pages 1515-1519 (May 2000) DOI: 10.1016/S0003-4975(00)01141-3

Fig 1 S-100 baseline values. p < 0.001 for healthy neonates (NB) versus all groups. (TGA = cyanotic neonates with d-transposition of the great arteries; DHCA = acyanotic neonates operated on in deep hypothermic cardiac arrest; ECC = acyanotic neonates operated on with extracorporeal circulation but without DHCA; CoA = neonates with aortic coarctation.) The Annals of Thoracic Surgery 2000 69, 1515-1519DOI: (10.1016/S0003-4975(00)01141-3)

Fig 2 Perioperative S-100 values. ∗p < 0.04; x, p < 0.001 for cyanotic neonates with d-transposition of the great arteries (TGA) versus all other groups. (DHCA = acyanotic neonates operated on in deep hypothermic cardiac arrest; ECC = acyanotic neonates operated on with extracorporeal circulation but without DHCA; CoA = neonates with aortic coarctation; Pre-op = preoperative; x-clamp = aortic cross-clamping; off-byp = off bypass; post-op = postoperative; 1. pod = first postoperative day; 3. pod = third postoperative day.) The Annals of Thoracic Surgery 2000 69, 1515-1519DOI: (10.1016/S0003-4975(00)01141-3)

Fig 3 Two neonates with acyanotic congenital heart disease operated on in deep hypothermic cardiac arrest (DHCA) with postoperative neurologic deficit compared with their group. Child A had correction of truncus arteriosus and generalized seizure postoperatively. Child B had correction of truncus arteriosus, evidence of cerebral damage in cranial ultrasound, and generalized seizure on the seventh postoperative day. (pre-op = preoperative; x-clamp = aortic cross-clamping; off-byp = off bypass; post-op = postoperative; 1. pod = first postoperative day; 3. pod = third postoperative day; 7. pod = seventh postoperative day.) The Annals of Thoracic Surgery 2000 69, 1515-1519DOI: (10.1016/S0003-4975(00)01141-3)

Fig 4 Two neonates after correction of d-transposition of the great arteries (TGA) and neurologic deficit compared with their group. Child C showed severe electroencephalographic changes and had multiple cerebral seizures after the operation. Child D had preoperative and postoperative evidence of discrete cerebral damage. (pre-op = preoperative; x-clamp = aortic cross-clamping; off-byp = off bypass; post-op = postoperative; 1. pod = first postoperative day; 3. pod = third postoperative day.) The Annals of Thoracic Surgery 2000 69, 1515-1519DOI: (10.1016/S0003-4975(00)01141-3)