TransDisciplinary Research in Traditional Medicine Rasayana Mode of Action

Health & Diseases Health Disease Biological System a. Enhanced structural features - Development - Maintenance - Regeneration b. Enhanced function c. Maintenance of structure and function Disease a. Infections b. Functional disorders c. Degenerative disorders

Contemporary Relevance Current mainstream healthcare system offers diagnosis tools and only symptomatic treatment for chronic diseases Lack of solutions for wellness and disease prevention Very few disease limiting and/or modifying drugs/practices Frequent side-effects Long and expensive procedure for developing a drug from a lead molecule

Contemporary Relevance Ayurveda can be useful for enhanced nervous system health Promotes/enhances health Possible preventive age related and life style disorders. Disease limiting/modifying ability Safe and easy way to improve or maintain nervous system health

Missing Links Clinical Lab Lack of integrative documentation for efficacy of the treatment inclusion objective assessment parameters protocols for assessment and treatment Lab Relevant model systems for translational research Understanding of mode of action of the FORMULATIONS at the cellular and molecular level

Rasayana Concept of Wellness Bridging Shastra and Science Concepts, Practice and Research Rasayana Concept of Wellness Rasayana tantra deals with anti-aging, strengthening, promoting longevity, retentive intelligence and curative measures of the diseases Shrotoshodhana Clearing of body channels Agnivyapara Optimization of metabolism Poshana Providing Nourishment

Pharmacological Understanding Bridging Shastra and Science Concepts, Practice and Research AYURVEDA Pharmacological Understanding Ashwagandha Withanis somnifera Brahmi Bacopa monnieri Amla Phylanthus emblica Dadima Punica granatum

Molecular and Cellular understanding Bridging Shastra and Science Concepts, Practice and Research MODERN SCIENCE Tools and Techniques Molecular and Cellular understanding

Promotive and Preventive Health & Diseases Biological System Health Promotive and Preventive Disease Disease modifying/ Management

Working Strategy AYURVEDA MODERN SCIENCE Practice Concepts Practice MODERN SCIENCE Clinical Research Mode of Action Research

Anaemia: A Metabolic Disorder Shrotoshodhana: Clear, Optimally Functional Body Channels Venkatasubramanian et al., 2013

Amla Enhances Bioavailability of Iron Anaemia: A Metabolic Disorder Agni Vyapara-Enhanced Metabolism Amla Enhances Bioavailability of Iron Amla Phylanthus emblica Venkatasubramanian et al., 2014

Piper longum Formulations Pippali is hot potency herb, so is piperine If taken as milk decoction it works better with less of side effects. Example: Antibiotic side effects TDU Data base, credits Dr. Venugopalan

Prevention and Promotion Dadima (Pomegranate) Enhances Life span and Healthspan Lifespan analysis Healthspan Climbing assay Fruit fly Drosophila melanogaster Balasubramani et al., 2014

Brahmi Improves Short Term Memory of Caenorhabditis elegans Prevention and Promotion Brahmi Improves Short Term Memory of Caenorhabditis elegans Brahmi Bacopa monnieri Rasa: Tikta, Kashaya Guna: Laghu, Pichhila Veerya: Sita Vipaka: Madhura

Clearing up the plaques Shrotishodhana or Agnivyapara? Treatment with Ashwagandha reduces plaque load in brains of Transgenic Mice with Alzheimer’s Disease Sehgal et al, 2015

Integrated clinical management Parkinson’s Disease Disease Treatment & Management Integrated clinical management Parkinson’s Disease Total UPDRS Score

Disease Model: Mode of Action Parkinson’s Disease Treatment protocol CONTROL CEP neurons L1 Larvae treated for 20h with 5mM MPP+ Degenerated CEP neurons Brahmi Mitigates MPP+ Iodide Induced Neurodegeneration in Parkinson’s Disease Model of Caenorhabditis elegans

Summary Modern BioMedicine Ayurveda Functional Science Structural Sciences Systems Perspective

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