Regional ventilation in cystic fibrosis measured by electrical impedance tomography Zhanqi Zhao, Rainald Fischer, Inéz Frerichs, Ullrich Müller-Lisse,

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Regional ventilation in cystic fibrosis measured by electrical impedance tomography Zhanqi Zhao, Rainald Fischer, Inéz Frerichs, Ullrich Müller-Lisse, Knut Möller Journal of Cystic Fibrosis Volume 11, Issue 5, Pages 412-418 (September 2012) DOI: 10.1016/j.jcf.2012.03.011 Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Difference images of one subject with healthy lungs at (a) 25%, (b) 50%, (c) 75% and (d) 100% of maximum inspiratory volume (difference to 0%). Color bars indicate the magnitude of relative impedance values in each pixel. Journal of Cystic Fibrosis 2012 11, 412-418DOI: (10.1016/j.jcf.2012.03.011) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Difference images of one CF patient at (a) 25%, (b) 50%, (c) 75% and (d) 100% of maximum inspiratory volume (difference to 0%). Color bars indicate the magnitude of relative impedance values in each pixel. Journal of Cystic Fibrosis 2012 11, 412-418DOI: (10.1016/j.jcf.2012.03.011) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 Comparison of GI index values at four lung volume levels at 25%, 50%, 75% and 100% of maximum inspiratory volume. CF: the GI values of 14 patients in the CF group; H: the GI of 14 healthy volunteers in the control group. The red lines indicate the median. The boxes mark the quartiles while the whiskers show the most extreme data values within 1.5 times the interquartile range of the sample. **P<0.01, 20% greater than the GI values of CF100. GI, global inhomogeneity, CF, cystic fibrosis, H, healthy. Journal of Cystic Fibrosis 2012 11, 412-418DOI: (10.1016/j.jcf.2012.03.011) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 4 Flow-volume curves of one CF patient, obtained from spirometry and EIT. a, b) global Flow-volume curves from spirometry and EIT, respectively. c,d) two exemplary regional Flow-volume curves from EIT. AU: arbitrary unit. Journal of Cystic Fibrosis 2012 11, 412-418DOI: (10.1016/j.jcf.2012.03.011) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 5 Comparison of regional MEF25/MEF75 maps between a healthy subject (left) and a CF patient (right) during forced expiration. Color bars indicate the ratio values in each pixel. Low MEF25/MEF75 values are marked in dark blue. Journal of Cystic Fibrosis 2012 11, 412-418DOI: (10.1016/j.jcf.2012.03.011) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 6 Normalized frequency distribution of regional MEF25/MEF75 for the patients in the CF group (bar in light grey, median) and the volunteers in the control group (bar in dark grey, median). Black lines on the bars indicate the upper (75%) and lower (25%) quartiles of the frequency in the CF group and in the control group. Journal of Cystic Fibrosis 2012 11, 412-418DOI: (10.1016/j.jcf.2012.03.011) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions