Clinical Situations Conducive to Proactive Skin Health and Anti-Aging Improvement Zoe Diana Draelos Journal of Investigative Dermatology Symposium Proceedings

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Clinical Situations Conducive to Proactive Skin Health and Anti-Aging Improvement Zoe Diana Draelos Journal of Investigative Dermatology Symposium Proceedings Volume 13, Issue 1, Pages 25-27 (April 2008) DOI: 10.1038/jidsymp.2008.9 Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Stratum corneum lipid organization in dry skin. Tape strips of environmentally dry leg skin were collected, fixed in Karnovsky's, post-fixed in 0.25% RuO4, dehydrated, and embedded for transmission electron microscopy. (a) Transmission electron microscopy of dry skin before treatment; note that intercellular regions are filled with amorphous material with sparse Landmann units (intercellular lamellar lipid). (b) The intercellular lipid structure improves after using a moisturizing body wash, with more Landmann units visible. Dry skin appearance also improved. Journal of Investigative Dermatology Symposium Proceedings 2008 13, 25-27DOI: (10.1038/jidsymp.2008.9) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 A high-depositing petrolatum-containing body wash (HDPCBW) improves barrier function compared to a regular body wash (RBW) followed by a dermatologist preferred petrolatum-based leave-on body lotion. Adult females (n=16) with environmentally dry leg skin underwent controlled leg washing for 21 days. TEWL measurements were taken at baseline and at day 21. TEWL, transepidermal water loss. Journal of Investigative Dermatology Symposium Proceedings 2008 13, 25-27DOI: (10.1038/jidsymp.2008.9) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Skin barrier enhancement by topical niacinamide. Adult female subjects (n=41) were treated with control versus 2% niacinamide for their forearm skin for 24 days, and TEWL was determined at the time points indicated in the graph. S indicates significance at P<0.002. TEWL, transepidermal water loss. Journal of Investigative Dermatology Symposium Proceedings 2008 13, 25-27DOI: (10.1038/jidsymp.2008.9) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions