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Volume 53, Issue 6, Pages 1783-1791 (June 1998) Perfusion quantitation in transplanted rat kidney by MRI with arterial spin labeling Jian-Jun Wang, Kristy S. Hendrich, Edwin K. Jackson, Suzanne T. Ildstad, Donald S. Williams, Chien Ho Kidney International Volume 53, Issue 6, Pages 1783-1791 (June 1998) DOI: 10.1046/j.1523-1755.1998.00945.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Expansions (2 cm × 2 cm) from representative MR images of rat kidney. Top row (A, B, C, and D) are anatomical images. Bottom row (E, F, G, and H) are the corresponding relative renal perfusion maps (percent changes in the magnetization due to spin labeling), where high perfusion rates are depicted as high intensity. The first two columns (A, E, B, and F) are from a normal rat, and the last two columns (C, G, D, and H) are from a rat seven days after allogeneic transplantation of the left kidney. Note the lack of detectable perfusion in the transplanted kidney (G), while cortical perfusion in the native kidney of the same animal (H) is similar to normal kidneys (E and F). A noticeable enlargement of the transplanted kidney can also be seen (C). Kidney International 1998 53, 1783-1791DOI: (10.1046/j.1523-1755.1998.00945.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Summary of the cortical perfusion data for all groups studied. Both left and right kidney results are pooled for the normal group. Error bars represent SD from the group mean. Abbreviations are: Syn, syngeneic; Allo, allogeneic; Tx., transplantation, *, no detectable perfusion, (that is, ≤ 0.3 ml/g/min). At day 3 post-transplantation, syn-Tx. versus allo-Tx., Pa > 0.05. At day 7, post-transplantation, syn Tx. versus normal F344 group, Pb > 0.05; allo-Tx. versus syn-Tx. or normal F344 group, Pc < 0.001. Kidney International 1998 53, 1783-1791DOI: (10.1046/j.1523-1755.1998.00945.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Correlation between the renal cortical perfusion rate and histological scores in transplanted kidneys. The correlation coefficient (r) was -0.82, P < 0.05 (N = 23). One value was an outlier. Kidney International 1998 53, 1783-1791DOI: (10.1046/j.1523-1755.1998.00945.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Correlation between the renal cortical perfusion and the cross-sectional area through transplanted kidneys as measured by MRI. The correlation coefficient (r) was -0.60, P < 0.01 (N = 22). Two values were outliers. Kidney International 1998 53, 1783-1791DOI: (10.1046/j.1523-1755.1998.00945.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 Correlation between the renal cortical perfusion rate and the cortical T1obs values in transplanted kidneys. The correlation coefficient (r) was -0.59, P < 0.05 for 20 studies. T1obs was not quantitated in 3 studies, due to motion artifacts, and one other value was an outlier. Kidney International 1998 53, 1783-1791DOI: (10.1046/j.1523-1755.1998.00945.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 6 Correlation between histological scores and cortical T1obs values in transplanted kidneys. The correlation coefficient (r) was -0.38, P = 0.23 for 20 studies. T1obs was not quantitated in 3 studies, due to motion artifacts, and one other value was an outlier. Kidney International 1998 53, 1783-1791DOI: (10.1046/j.1523-1755.1998.00945.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 7 Serum levels of blood urea nitrogen (BUN) and creatinine in normal rats (F344, N = 5; ACI, N = 5) and syngeneic renal transplanted rats (Syn-Tx.) at days 3, 7, and 14 post-transplantation (N = 5). Error bars represent SD from the group mean. (For BUN level at day 3, syn-Tx. group vs. normal F344 or ACI group, Pa < 0.005; for creatinine, Pb > 0.05). Kidney International 1998 53, 1783-1791DOI: (10.1046/j.1523-1755.1998.00945.x) Copyright © 1998 International Society of Nephrology Terms and Conditions