Prevalence of Heparin/Platelet Factor 4 Antibodies Before and After Cardiac Surgery Brendan M. Everett, MD, Robert Yeh, MD, Shi Yin Foo, MD, PhD, David.

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Prevalence of Heparin/Platelet Factor 4 Antibodies Before and After Cardiac Surgery Brendan M. Everett, MD, Robert Yeh, MD, Shi Yin Foo, MD, PhD, David Criss, MD, Elizabeth M. Van Cott, MD, Michael Laposata, MD, PhD, Edwin G. Avery, MD, William D. Hoffman, MD, Jennifer Walker, MD, David Torchiana, MD, Ik-Kyung Jang, MD, PhD The Annals of Thoracic Surgery Volume 83, Issue 2, Pages 592-597 (February 2007) DOI: 10.1016/j.athoracsur.2006.09.040 Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Prevalence of heparin/platelet factor 4 antibodies before (pre) and after (post) cardiac surgery. The prevalence of heparin/platelet factor 4 antibodies increased more than fivefold after cardiac surgery. The Annals of Thoracic Surgery 2007 83, 592-597DOI: (10.1016/j.athoracsur.2006.09.040) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Frequency of thromboembolic events according to the presence or absence of antibodies to heparin/platelet factor 4 (A); frequency of thromboembolic events according to the presence or absence of postoperative thrombocytopenia (defined as a platelet count <100,000 or a fall of >50% from preoperative levels), regardless of the presence or absence of the antibody to heparin/platelet factor 4 (B); and frequency of thromboembolic events according to the presence or absence of clinical heparin-induced thrombocytopenia (HIT; defined as a positive postoperative heparin/platelet factor 4 antibody test with thrombocytopenia) (C). The Annals of Thoracic Surgery 2007 83, 592-597DOI: (10.1016/j.athoracsur.2006.09.040) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions