Volume 56, Pages S202-S205 (July 1999)

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Volume 56, Pages S202-S205 (July 1999) Effects of lovastatin on expression of cell cycle regulatory proteins in vascular smooth muscle cells Hiroaki Oda, Bertram L. Kasiske, Michael P. O’Donnell, Ph.D., William F. Keane Kidney International Volume 56, Pages S202-S205 (July 1999) DOI: 10.1046/j.1523-1755.1999.07152.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 DNA synthesis in cultured rat vascular smooth muscle cells (VSMCs) stimulated by platelet-derived growth factor (PDGF). DNA synthesis was suppressed by lovastatin pretreatment for nine hours prior to PDGF stimulation. Triangles, VSMCs + PDGF 25 ng/ml; squares, VSMCs + lovastatin (20 μM) pretreatment prior to PDGF stimulation; circles, control VSMCs maintained in 0.2% heat-inactivated fetal bovine serum. Data represent means ± SD of three experiments. Kidney International 1999 56, S202-S205DOI: (10.1046/j.1523-1755.1999.07152.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Western blot analysis of expression of cell cycle regulatory proteins in cultured rat vascular smooth muscle cells (VSMCs). (A) Cyclin D1. (B) Cyclin E. (C) CDK 4. (D) CDK2. (E) p27Kip1. Molecular weight of each cell-cycle protein is cyclin D1, 36 kDa; cyclin E, 42 and 50 kDa; CDK4, 34 kDa; CDK2, 33 kDa. Culture conditions are (a) control VSMCs incubated in 0.2% heat-inactivated fetal bovine serum; (b) VSMCs + PDGF (25 ng/ml); and (c) VSMCs + lovastatin (20 μM) pretreatment for nine hours prior to PDGF stimulation. Optical density (O.D.) of the autoradiogram at time 0 was determined as baseline (O.D. = 1.0). Data in graphs represent the ratios of O.D. values. Kidney International 1999 56, S202-S205DOI: (10.1046/j.1523-1755.1999.07152.x) Copyright © 1999 International Society of Nephrology Terms and Conditions