The effect of anterior cruciate ligament injury on bone curvature: exploratory analysis in the KANON trial D.J. Hunter, L.S. Lohmander, J. Makovey, J.

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Presentation transcript:

The effect of anterior cruciate ligament injury on bone curvature: exploratory analysis in the KANON trial D.J. Hunter, L.S. Lohmander, J. Makovey, J. Tamez-Peña, S. Totterman, E. Schreyer, R.B. Frobell Osteoarthritis and Cartilage Volume 22, Issue 7, Pages 959-968 (July 2014) DOI: 10.1016/j.joca.2014.05.014 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Example image of one KANON study participant (study ID K-C-1052). Fat suppressed image at baseline and 5 year follow-up along with 3D bone surface models illustrating BCI curvature of the femur at baseline and 5 years. Notice the changes of the shape of the trochlea (long arrow at baseline and 5 years) and flattening of the articulating tibia and femur bone surfaces (short arrows at baseline and 5 years) shown in the MR images. The same curvature changes are depicted in the color coded curvature maps of the femur. Osteoarthritis and Cartilage 2014 22, 959-968DOI: (10.1016/j.joca.2014.05.014) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Cohort-based/population average maps. Left Panel: Baseline measures for the tibia and femur. Middle panel 2 year bone curvature change for femur (above) and tibia (below). Right panel 5 year change for femur (above) and tibia (below). Maps are based on 93 of the 111 participants with both good reference atlas-segmentation and paired data at baseline, 2 and 5 years. Osteoarthritis and Cartilage 2014 22, 959-968DOI: (10.1016/j.joca.2014.05.014) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Trajectory of bone curvature over the five year follow-up period by anatomic location. Data points represent means with 95% confidence intervals. a. Left panel. Intense follow-up group with repeat observations at multiple time points. Sample size at baseline (0 months) (n = 64); 3 months (n = 62); 6 months (n = 61); 12 months (n = 61); 24 months (n = 61); 60 months (n = 61). b. Right panel. Whole cohort follow-up with observations at baseline, 2 years and 5 years. Sample size at baseline (0 months (n = 111); 24 months (n = 111); 60 months (n = 111). Osteoarthritis and Cartilage 2014 22, 959-968DOI: (10.1016/j.joca.2014.05.014) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Curvature change over 5 years by treatment group. Bars represent mean curvature change between baseline (0 months) and 5 years (n = 111) with 95% confidence intervals. Osteoarthritis and Cartilage 2014 22, 959-968DOI: (10.1016/j.joca.2014.05.014) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions