Analysis of Hair Follicles in Mutant Laboratory Mice

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Presentation transcript:

Analysis of Hair Follicles in Mutant Laboratory Mice John P. Sundberg, Eva M.J. Peters, Ralf Paus Journal of Investigative Dermatology Symposium Proceedings Volume 10, Issue 3, Pages 264-270 (December 2005) DOI: 10.1111/j.1087-0024.2005.10126.x Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Anagen stage vibrissa follicle illustrating the anatomic features unique to this structure and also the major parts of a follicle actively producing a hair fiber. I, infundibulum; IS, isthmus; LF, lower follicle; HR, hair root; SGD, salivary gland duct; SG, salivary gland; ORS, outer root sheath; IRS, inner root sheath; HF, hair fiber; S, blood-filled sinus; N, nerve; CH, club hair; PC, pre-cortex; DP, dermal papilla; and HM, hair matrix. Journal of Investigative Dermatology Symposium Proceedings 2005 10, 264-270DOI: (10.1111/j.1087-0024.2005.10126.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Schematic representation of hair follicle morphogenesis and the subsequent first hair cycle. This drawing depicts key stages of hair follicle development and cycling in the dorsal skin of a mouse. Blue lines indicate nerve fibers and red structures indicate accompanying blood vessels. APM, arrector pili muscle; BM, basement membrane; BV, blood vessel; DP, dermal papilla; HM, hair matrix, HS, hair shaft; IRS, inner root sheath; mel, melanocyte; ORS, outer root sheath; SG, sebaceous gland. Journal of Investigative Dermatology Symposium Proceedings 2005 10, 264-270DOI: (10.1111/j.1087-0024.2005.10126.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Anatomic variations of different hair types in the mouse. Tail skin, anagen (A); truncal skin, anagen (B); perianal hair, anagen (C); vibrissa and large non-sinusoidal hair in muzzle skin, anagen (D); and eyelid mucocutaneous junction, telogen ((E), cilia and Meibomian gland). Journal of Investigative Dermatology Symposium Proceedings 2005 10, 264-270DOI: (10.1111/j.1087-0024.2005.10126.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions