Clinical significance and determinants of the universal definition of perioperative bleeding classification in patients undergoing coronary artery bypass.

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Presentation transcript:

Clinical significance and determinants of the universal definition of perioperative bleeding classification in patients undergoing coronary artery bypass surgery  Eeva-Maija Kinnunen, MS, Tatu Juvonen, MD, PhD, Kari Eino Juhani Airaksinen, MD, PhD, Jouni Heikkinen, MD, PhD, Ulla Kettunen, RN, Giovanni Mariscalco, MD, PhD, Fausto Biancari, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 148, Issue 4, Pages 1640-1646.e2 (October 2014) DOI: 10.1016/j.jtcvs.2014.07.040 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Postoperative rates of in-hospital mortality (P < .0001), stroke (P < .0001), renal replacement therapy (P < .0001), and low cardiac output (cardiac index < 2.0 L/min/m2 for ≥2 different measurements, P < .0001) stratified by universal definition of perioperative bleeding class. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1640-1646.e2DOI: (10.1016/j.jtcvs.2014.07.040) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Cox proportional hazards estimate of late survival after coronary artery bypass surgery stratified by universal definition of perioperative bleeding (UDPB) class (adjusted analysis for age, estimated glomerular filtration rate, diabetes, extracardiac arteriopathy, and left ventricular ejection fraction: P < .0001, class 1: hazard ratio [HR], 0.894; 95% confidence interval [CI], 0.485-1.650; class 2: HR, 1.665; 95% CI, 1.142-2.427; class 3: HR, 2.092; 95% CI, 1.411-3.101; class 4: HR, 4.651; 95% CI, 2.819-7.675). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1640-1646.e2DOI: (10.1016/j.jtcvs.2014.07.040) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions