Simon Haas, Andreas Trumpp Developmental Cell

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An Intrinsic Interferon Program Protects Stem Cells from Viral Infection Simon Haas, Andreas Trumpp Developmental Cell Volume 44, Issue 3, Pages 279-280 (February 2018) DOI: 10.1016/j.devcel.2018.01.013 Copyright © 2018 Terms and Conditions

Figure 1 Intrinsic ISG Expression Protects Stem Cells from Viral Infection Stem cells express high levels of interferon-stimulated genes (ISGs) in the absence of infection. This protects them from viral infection. However, stem cells are refractory to acute interferon (IFN) signaling. Upon differentiation, cells decrease intrinsic ISG expression, become sensitive to acute IFNs during inflammatory responses, and become susceptible to viral infection. Developmental Cell 2018 44, 279-280DOI: (10.1016/j.devcel.2018.01.013) Copyright © 2018 Terms and Conditions