Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems –

Slides:



Advertisements
Similar presentations
Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.
Advertisements

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.
2D and 3D MOCART scoring systems assessed by 9
T. Maerz, M. D. Newton, K. Kristof, O. Motovylyak, J. S. Fischgrund, D
Association of knee and ankle osteoarthritis with physical performance
H.J. Smith, Ph.D., J.B. Richardson, M.D., A. Tennant, Ph.D. 
One-stage focal cartilage defect treatment with bone marrow mononuclear cells and chondrocytes leads to better macroscopic cartilage regeneration compared.
The groove model of osteoarthritis applied to the ovine fetlock joint
Osteoclasts are recruited to the subchondral bone in naturally occurring post-traumatic equine carpal osteoarthritis and may contribute to cartilage degradation 
The epidemiology and impact of pain in osteoarthritis
Validity and sensitivity to change of three scales for the radiographic assessment of knee osteoarthritis using images from the Multicenter Osteoarthritis.
Evaluation of native hyaline cartilage and repair tissue after two cartilage repair surgery techniques with 23Na MR imaging at 7 T: initial experience 
In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis  N.H. Lim, E. Meinjohanns, M. Meldal, G.
Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters  A. Hanifi, J.B. Richardson,
L.N. Nwosu, P.I. Mapp, V. Chapman, D.A. Walsh 
Protective effect of a new biomaterial against the development of experimental osteoarthritis lesions in rabbit: a pilot study evaluating the intra-articular.
Direct bone morphogenetic protein 2 and Indian hedgehog gene transfer for articular cartilage repair using bone marrow coagulates  J.T. Sieker, M. Kunz,
Experimental scoring systems for macroscopic articular cartilage repair correlate with the MOCART score assessed by a high-field MRI at 9.4 T – comparative.
Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects.
Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives  Y. Henrotin  Osteoarthritis and Cartilage 
Direct bone morphogenetic protein 2 and Indian hedgehog gene transfer for articular cartilage repair using bone marrow coagulates  J.T. Sieker, M. Kunz,
A novel exogenous concentration-gradient collagen scaffold augments full-thickness articular cartilage repair  T. Mimura, M.D., S. Imai, M.D., M. Kubo,
B. Bittersohl, F. R. Miese, H. S. Hosalkar, M. Herten, G. Antoch, R
Relationship between pre-radiographic cartilage damage following anterior cruciate ligament injury and biomarkers of cartilage turnover in clinical practice:
B. Kaleem, F. Maier, H. Drissi, D.M. Pierce 
Mechanical response of articular cartilage damaged by macro cracks
P. Julkunen, J. Iivarinen, P. A. Brama, J. Arokoski, J. S. Jurvelin, H
Histopathology grading systems for characterisation of human knee osteoarthritis – reproducibility, variability, reliability, correlation, and validity 
Temporal and spatial migration pattern of the subchondral bone plate in a rabbit osteochondral defect model  P. Orth, M. Cucchiarini, G. Kaul, M.F. Ong,
Time to be positive about negative data?
Pretreatment of periosteum with TGF-β1 in situ enhances the quality of osteochondral tissue regenerated from transplanted periosteal grafts in adult rabbits 
A.C. Dang, M.D., A.P. Warren, M.D., H.T. Kim, M.D., Ph.D. 
Structural adaptations in compressed articular cartilage measured by diffusion tensor imaging  S.K. de Visser, B.Eng. (Med.), R.W. Crawford, D.Phil.,
M. Cucchiarini, H. Madry, E.F. Terwilliger 
Stem cell therapy for human cartilage defects: a systematic review
Utility of T2 mapping and dGEMRIC for evaluation of cartilage repair after allograft chondrocyte implantation in a rabbit model  J. Endo, A. Watanabe,
Quantitative MR T2 measurement of articular cartilage to assess the treatment effect of intra-articular hyaluronic acid injection on experimental osteoarthritis.
The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the dog  J.L. Cook, K. Kuroki, D. Visco, J.-P.
Expression of the PTH/PTHrP receptor in chondrogenic cells during the repair of full- thickness defects of articular cartilage  H. Mizuta, M.D., Ph.D.,
K. Rahunen, L. Rieppo, P. Lehenkari, M. Finnilä, S. Saarakkala 
H. Sadeghi, D.E.T. Shepherd, D.M. Espino  Osteoarthritis and Cartilage 
N. Männicke, M. Schöne, M. Oelze, K. Raum  Osteoarthritis and Cartilage 
Utilization rates of hip arthroplasty in OECD countries
Cartilaginous repair of full-thickness articular cartilage defects is induced by the intermittent activation of PTH/PTHrP signaling  S. Kudo, H. Mizuta,
Scientific production and impact of national registers: the example of orthopaedic national registers  P. Boyer, I. Boutron, P. Ravaud  Osteoarthritis.
Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis  M. Blagojevic, C. Jinks, A. Jeffery, K.P.
The effects of alendronate in the treatment of experimental osteonecrosis of the hip in adult rabbits  J.G. Hofstaetter, M.D., J. Wang, M.D., Ph.D., J.
A graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open- source tool for histological grading  H.E. Kloefkorn, B.Y. Jacobs,
Who should have a joint replacement? A plea for more ‘phronesis’
V.K. Shekhawat, M.P. Laurent, C. Muehleman, M.A. Wimmer 
Lower cervical spine facet cartilage thickness mapping
Early Alterations in Articular Cartilage Surface topography in Post-traumatic Equine Model of Osteoarthritis  S.M. Tabbaa, V.W. Wong, G. Silberman, C.W.
Microfracture and bone morphogenetic protein 7 (BMP-7) synergistically stimulate articular cartilage repair  A.C. Kuo, M.D., Ph.D., J.J. Rodrigo, M.D.,
D.J. Hunter  Osteoarthritis and Cartilage 
Osteoarthritis and Cartilage
S.G. Muthuri, D.F. McWilliams, M. Doherty, W. Zhang 
I. G. Otterness, Ph. D. , M. -P. H. Le Graverand, M. D. , Ph. D. , F
Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study  C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu 
Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA- Quest): a psychometric study  L. Busija, R. Buchbinder, R.H. Osborne  Osteoarthritis.
Correlation between the MR T2 value at 4
Osteoarthritis year 2012 in review: biology
Systematic review of the impact of osteoarthritis on health outcomes for comorbid disease in older people  L. Parkinson, D.L. Waters, L. Franck  Osteoarthritis.
D.T. Felson  Osteoarthritis and Cartilage 
H. Khan, D. Aitken, C. Ding, L. Blizzard, J. -P. Pelletier, J
The effect of platelet rich plasma combined with microfractures on the treatment of chondral defects: an experimental study in a sheep model  G. Milano,
Effects of helium–neon laser on the mucopolysaccharide induction in experimental osteoarthritic cartilage  Y.-S. Lin, M.Sc, Dr M.-H. Huang, M.D., Ph.D.,
Osteoarthritis year in review 2016: mechanics
S. Reichenbach, P. Jüni, E. Nüesch, F. Frey, R. Ganz, M. Leunig 
M. Doherty, P. Dieppe  Osteoarthritis and Cartilage 
General Information Osteoarthritis and Cartilage
Presentation transcript:

Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems – a study in adult sheep  L. Goebel, P. Orth, M. Cucchiarini, D. Pape, H. Madry  Osteoarthritis and Cartilage  Volume 25, Issue 4, Pages 581-588 (April 2017) DOI: 10.1016/j.joca.2016.10.014 Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Representative macroscopic and histological images with poor (a–c), intermediate (d–f) and good (g–i) results as observed in this study according to the Sellers score. The red squares in a, d and g refer to the histological images in b, e and h; while the red squares in b, e and h depict to the detail images c, f and I, respectively. Asterisks refer to persistent drill holes observed 6 month after Pridie drilling. Osteoarthritis and Cartilage 2017 25, 581-588DOI: (10.1016/j.joca.2016.10.014) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Relationship between macroscopic and histological scoring systems for key categories of articular cartilage repair. Macroscopic parameters (ordinate) were plotted against histological categories (abscissa). Columns: left – Wakitani score, right – Sellers score; rows: first – “defect fill”, second – “surface”, last – “total points”. Significant correlations exist between all scores for “defect fill” and “total points”, while no correlation was found for “surface”. For details and linear correlation analyses see Table III. Osteoarthritis and Cartilage 2017 25, 581-588DOI: (10.1016/j.joca.2016.10.014) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions