Application of AdvaSeal for acute aortic dissection: experimental study Keita Tanaka, MD, Shinichi Takamoto, MD, Toshiya Ohtsuka, MD, Yutaka Kotsuka,

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Presentation transcript:

Application of AdvaSeal for acute aortic dissection: experimental study Keita Tanaka, MD, Shinichi Takamoto, MD, Toshiya Ohtsuka, MD, Yutaka Kotsuka, MD, Motohiro Kawauchi, MD The Annals of Thoracic Surgery Volume 68, Issue 4, Pages 1308-1312 (October 1999) DOI: 10.1016/S0003-4975(99)00757-2

Fig 1 AdvaSeal sealant system; disposable sealant (S) and primer (P) applicators, light source (L) and light wand (W). The sealant is provided in frozen form, and is thawed until completely liquid before application. Following application of primer solution, sealant solution is applied and exposed to xenon light. The Annals of Thoracic Surgery 1999 68, 1308-1312DOI: (10.1016/S0003-4975(99)00757-2)

Fig 2 (A) Intraoperative photograph demonstrating surgically created acute dissection of canine descending aorta (white arrows). (B) Ultrasonography of long-axis view of dissected aorta demonstrating intimal flap. (C) Doppler ultrasonography of short-axis view of dissected aorta showing normograde blood flow. T = true lumen; F = false lumen. The Annals of Thoracic Surgery 1999 68, 1308-1312DOI: (10.1016/S0003-4975(99)00757-2)

Fig 3 Intraoperative photograph showing the device applied to a dissected aorta. (S = sealant; W = light wand.) The Annals of Thoracic Surgery 1999 68, 1308-1312DOI: (10.1016/S0003-4975(99)00757-2)

Fig 4 Photomicrographs of cross sections of canine descending aortas taken from the control group on day 15 (A) and AdvaSeal group on day 17 (B). In the control group, false lumen (∗) was patent and covered with hyperplastic neointima (arrow head). In AdvaSeal group, false lumen was entirely closed with AdvaSeal (arrow) and thrombus. Nonspecific inflammatory response was observed in the adventitia. Media and intima was intact. (Elastica-van Gieson stain; original magnification of ×40). The Annals of Thoracic Surgery 1999 68, 1308-1312DOI: (10.1016/S0003-4975(99)00757-2)