Primary thoracic cavity gastrointestinal stromal tumor

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Presentation transcript:

Primary thoracic cavity gastrointestinal stromal tumor Ji-Wei Cheng, MSc, Shao-Hua Lu, MD, Song-Tao Xu, MD, Hao Wang, MD, Ying-Yong Hou, MD, PhD, Ru-Heng Zheng, MD, Yun-Shan Tan, MD The Journal of Thoracic and Cardiovascular Surgery Volume 140, Issue 2, Pages e29-e31 (August 2010) DOI: 10.1016/j.jtcvs.2010.01.005 Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, X-ray film showed dense shadow in the middle and lower lobe of the right lung. B, Computed tomographic scan depicting a huge heterogeneous mass measuring 14.2 cm anteroposteriorly, 13.2 cm transversely and 16.4 cm craniocaudally in the right thoracic cavity. C, Computed tomographic findings. A large tumor (long arrow) of 5 cm in diameter involved diaphragm and diaphragmatic surface of the right lower lung. A small tumor (short arrow) of 1 cm in diameter was in the lateral segment of the right lower lung. D, Gross findings of the resected tumor. The tumor was white in cut surface and had a clear boundary with lung tissue, measuring 5 × 4 × 4 cm in size. The Journal of Thoracic and Cardiovascular Surgery 2010 140, e29-e31DOI: (10.1016/j.jtcvs.2010.01.005) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 A, Microscopically, the tumor had uniform spindle cells with a moderate degree of nuclear pleomorphism. B, Immunohistochemical studies showed positive staining for CD117 (c-kit). C, Genetic analyses revealed loss of heterozygosity at codon (the arrow indicates the beginning mutation locus) 567–576 of exon 11 of the c-kit gene accompanied AAG GAA insertion. The Journal of Thoracic and Cardiovascular Surgery 2010 140, e29-e31DOI: (10.1016/j.jtcvs.2010.01.005) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions