The 19S Cap Puzzle: A New Jigsaw Piece

Slides:



Advertisements
Similar presentations
Early Folding Events Protect Aggregation-Prone Regions of a β-Rich Protein Ivan L. Budyak, Beena Krishnan, Anna M. Marcelino-Cruz, Mylene C. Ferrolino,
Advertisements

Site-Directed Mutagenesis Demonstrates the Plasticity of the β Helix: Implications for the Structure of the Misfolded Prion Protein Jay H. Choi, Barnaby.
Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis John Hines, Michael Groll, Margaret Fahnestock, Craig M. Crews Chemistry &
Toward a Structure Determination Method for Biomineral-Associated Protein Using Combined Solid- State NMR and Computational Structure Prediction David.
Recognizing Protein-Ligand Binding Sites by Global Structural Alignment and Local Geometry Refinement Ambrish Roy, Yang Zhang Structure Volume 20, Issue.
Biogenesis of Nascent High Density Lipoprotein Particles
Adam W. Van Wynsberghe, Qiang Cui  Structure 
Biology of Amyloid: Structure, Function, and Regulation
PARG: A Macrodomain in Disguise
Liam M. Longo, Ozan S. Kumru, C. Russell Middaugh, Michael Blaber 
Robert Englmeier, Stefan Pfeffer, Friedrich Förster  Structure 
Deubiquitination of Lys63-Linkage by a CYLD UBP
Generalizable Learning: Practice Makes Perfect — But at What?
Sebastian Meyer, Raimund Dutzler  Structure 
Natalie Zeytuni, Raz Zarivach  Structure 
Volume 13, Issue 12, Pages (December 2005)
Volume 20, Issue 6, Pages (June 2012)
Amyloid Structures from Alzheimer’s Disease Patients
Blocking HIV-1 gp120 at the Phe43 Cavity: If the Extension Fits…
Deubiquitination of Lys63-Linkage by a CYLD UBP
Volume 18, Issue 8, Pages (August 2010)
Structure Prediction: How good are we?
Srayanta Mukherjee, Yang Zhang  Structure 
PhnK: Another Piece of the Carbon-Phosphorus Lyase Puzzle
Volume 20, Issue 6, Pages (June 2012)
Chaperone-Assisted Crystallography with DARPins
Oxygen, Metabolism, and Gene Expression: The T-Rex Connection
Volume 24, Issue 3, Pages (March 2016)
Structure of the Oligosaccharyl Transferase Complex at 12 Å Resolution
Frank Alber, Michael F. Kim, Andrej Sali  Structure 
Nadine Keller, Jiří Mareš, Oliver Zerbe, Markus G. Grütter  Structure 
Volume 25, Issue 1, Pages (January 2017)
A Highly Strained Nuclear Conformation of the Exportin Cse1p Revealed by Molecular Dynamics Simulations  Ulrich Zachariae, Helmut Grubmüller  Structure 
The 3D Structure of Villin as an Unusual F-Actin Crosslinker
Volume 18, Issue 9, Pages (September 2010)
Multiple Conformations of F-actin
Volume 24, Issue 6, Pages (June 2016)
Shuchismita Dutta, Helen M. Berman  Structure 
Volume 124, Issue 5, Pages (March 2006)
Structural Basis for Vertebrate Filamin Dimerization
Srayanta Mukherjee, Yang Zhang  Structure 
Volume 20, Issue 3, Pages (March 2012)
Volume 21, Issue 6, Pages (June 2013)
Alternative Folding Nuclei Definitions Facilitate the Evolution of a Symmetric Protein Fold from a Smaller Peptide Motif  Liam M. Longo, Jihun Lee, Connie A.
Volume 20, Issue 3, Pages (March 2012)
Structure of the Catalytic Region of DNA Ligase IV in Complex with an Artemis Fragment Sheds Light on Double-Strand Break Repair  Takashi Ochi, Xiaolong.
Probing the “Dark Matter” of Protein Fold Space
Insights into Oncogenic Mutations of Plexin-B1 Based on the Solution Structure of the Rho GTPase Binding Domain  Yufeng Tong, Prasanta K. Hota, Mehdi.
Helen M. Berman, Gerard J. Kleywegt, Haruki Nakamura, John L. Markley 
Amyloid Structures from Alzheimer’s Disease Patients
Breaking Down Order to Keep Cells Tidy
Understanding CARD Tricks in Apoptosomes
Volume 13, Issue 3, Pages (March 2005)
Fibronectin Structure: A New Piece of the Puzzle Emerges
Automated Prediction of Protein Association Rate Constants
Yan Xia, Axel W. Fischer, Pedro Teixeira, Brian Weiner, Jens Meiler 
AMPK and SNF1: Snuffing Out Stress
Transmuting α helices and β sheets
The NPC-Transporter, A Ghost in the Machine
Ethan B. Butler, Yong Xiong, Jimin Wang, Scott A. Strobel 
Volume 26, Issue 3, Pages e3 (March 2018)
Volume 20, Issue 4, Pages (April 2012)
Molecular Similarity Analysis Uncovers Heterogeneous Structure-Activity Relationships and Variable Activity Landscapes  Lisa Peltason, Jürgen Bajorath 
Volume 17, Issue 2, Pages (February 2009)
Eva M. Huber, Michael Groll  Structure 
Damian Dawidowski, David S. Cafiso  Structure 
Volume 22, Issue 11, Pages (November 2014)
Toward a Structural Understanding of Arf Family:Effector Specificity
Qing Yao, Sara J. Weaver, Jee-Young Mock, Grant J. Jensen  Structure 
Shuchismita Dutta, Helen M. Berman  Structure 
Presentation transcript:

The 19S Cap Puzzle: A New Jigsaw Piece Eva M. Huber, Michael Groll  Structure  Volume 20, Issue 3, Pages 387-388 (March 2012) DOI: 10.1016/j.str.2012.02.006 Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 1 Structural Comparison of Prominent Proteins with Solenoid Fold The crystal structures of Rpn2 (green; Protein Data Bank [PDB] ID 4ADY), Blm10 (red; PDB ID 1VSY), and importin-β (blue; PDB ID 1QGK) are shown. The size of the structures indicates their real proportions. (Left) Top view on the solenoid structures of Rpn2 (104 kDa), Blm10 (246 kDa), and importin-β (97 kDa). (Right) Side view on Rpn2, Blm10, and importin-β. The α helices of the toroid-like fold are oriented horizontally. Structure 2012 20, 387-388DOI: (10.1016/j.str.2012.02.006) Copyright © 2012 Elsevier Ltd Terms and Conditions