Yuzhe Feng, Felix J. Schlösser, MD, PhD, Bauer E. Sumpio, MD, PhD

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The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy Yuzhe Feng, Felix J. Schlösser, MD, PhD, Bauer E. Sumpio, MD, PhD Journal of Vascular Surgery Volume 50, Issue 3, Pages 675-682.e1 (September 2009) DOI: 10.1016/j.jvs.2009.05.017 Copyright © 2009 Society for Vascular Surgery Terms and Conditions

Fig 1 Summary of the article selection process. Journal of Vascular Surgery 2009 50, 675-682.e1DOI: (10.1016/j.jvs.2009.05.017) Copyright © 2009 Society for Vascular Surgery Terms and Conditions

Fig 2 The sensitivity, specificity, PPV, and NPV of SWME were compared with different reference tests as presented in the literature. The first column shows the reference test that was used for the comparisons. The second column shows specific descriptions of the study populations and detailed information regarding the methodology of SWME in the identified articles. Articles with identical methods of SWME and reference tests were grouped. The last four columns present the sensitivity, specificity, PPV, and NPV for each method of SWME given a specific reference test. SWME, Semmes Weinstein monofilament examination; DM, diabetes mellitus; NDM, patients without diabetes mellitus in the reference group; Sens., sensitivity; Spec., specificity; PPV, positive predictive value; NPV, negative predictive value; VPT, vibration perception threshold. aThe fractions in the SWME column show the threshold for diagnosis/the number of sites tested. Ex: 1/2 sites on each foot means the inability to detect one site out of two sites on each foot was considered DPN. bThe calculations necessary for rows F and I were done by combining the crude number of subjects from all studies in the specific category. cTwo positive out of the three tests: numbness in both legs; diminished reflex in both legs; VPT score below 4. Journal of Vascular Surgery 2009 50, 675-682.e1DOI: (10.1016/j.jvs.2009.05.017) Copyright © 2009 Society for Vascular Surgery Terms and Conditions

Fig 3 The sensitivities of SWME as indicated in Fig 2 are shown along with 95% CI. Letters in the horizontal axis correspond to the “10 g SWME/Domain” column in Fig 2. Journal of Vascular Surgery 2009 50, 675-682.e1DOI: (10.1016/j.jvs.2009.05.017) Copyright © 2009 Society for Vascular Surgery Terms and Conditions

Fig 4 The specificities of SWME as indicated in Fig 2 are shown along with 95% CI. Letters in the horizontal axis correspond to the “10 g SWME/Domain” column in Fig 2. Journal of Vascular Surgery 2009 50, 675-682.e1DOI: (10.1016/j.jvs.2009.05.017) Copyright © 2009 Society for Vascular Surgery Terms and Conditions