Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia Y.Joseph Woo, MD, Matthew D Taylor, BS,

Slides:

Advertisements

Similar presentations

Max B. Mitchell, MD The Journal of Thoracic and Cardiovascular Surgery

Advertisements

Manuel J. Antunes, MD, PhD, DSc

Reduction of systolic and diastolic dysfunction by retrograde coronary sinus perfusion during off-pump coronary surgery Manuel Castellá, MD, Gerald D.

Simvastatin attenuates cardiac isograft ischemia-reperfusion injury by down-regulating CC chemokine receptor-2 expression Rong Yin, MD, Jiaquan Zhu,

Hypercholesterolemia and chronic ischemia alter myocardial responses to selective cyclooxygenase-2 inhibition Louis M. Chu, MD, Michael P. Robich, MD,

Hemodynamics and myocardial blood flow patterns after placement of a cardiac passive restraint device in a model of dilated cardiomyopathy Jennifer A.

Creating an ideal “off-test mode” for rotary left ventricular assist devices: Establishing a safe and appropriate weaning protocol after myocardial recovery

Prediction of severe acute kidney injury after pediatric cardiac surgery with the use of novel biomarkers: A new trend in clinical research and risk stratification

Functional evaluation of human donation after cardiac death donor hearts using a continuous isolated myocardial perfusion technique: Potential for expansion.

Prolonged donor heart preservation with pinacidil: The role of mitochondria and the mitochondrial adenosine triphosphate–sensitive potassium channel

Is hyperglycemia bad for the heart during acute ischemia?

Alan P. Kypson, MD, David W. Frazier, MD, Jon F. Moran, MD

Nitric oxide–generating β-adrenergic blocker nipradilol preserves postischemic cardiac function Hitoshi Horimoto, MD, Adam E Saltman, MD, PhD, Glenn.

Cardiac pheochromocytoma

Inhaled nitric oxide reduces ischemia-reperfusion injury in rat lungs from non–heart- beating donors Seiki Takashima, MD, Giovanna Koukoulis, MD, Hidetoshi.

Building a bioartificial heart: A 3-song saga

Which is more important in the potential interference on cardioprotection by remote ischemic preconditioning: β-blockers or anesthetic choice? Yang Liu,

Juan A. Crestanello, MD, Richard C. Daly, MD

Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure Mark F. Berry, MD, Timothy.

Centers for Disease Control “increased-risk” organ donor: Not so risky? Francis D. Pagani, MD, PhD The Journal of Thoracic and Cardiovascular Surgery

Form ever follows function

Left ventricular unloading before reperfusion reduces endothelin-1 release and calcium overload in porcine myocardial infarction Sophie Tamareille, PhD,

William M. DeCampli, MD, PhD

A new approach: Ischemic mitral regurgitation guidelines by and for surgeons Patrick M. McCarthy, MD The Journal of Thoracic and Cardiovascular Surgery

Single-dose rosuvastatin ameliorates lung ischemia–reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage.

Impact of prior hospital mortality versus surgical volume on mortality following surgery for congenital heart disease Matthew E. Oster, MD, Matthew J.

Intermittent aortic crossclamping prevents cumulative adenosine triphosphate depletion, ventricular fibrillation, and dysfunction (stunning): Is it preconditioning?

Myocardial rescue with autologous mitochondrial transplantation in a porcine model of ischemia/reperfusion Aditya K. Kaza, MD, Isaac Wamala, MD, Ingeborg.

Natural history of coexistent tricuspid regurgitation in patients with degenerative mitral valve disease: Implications for future guidelines Andrew B.

Juan N. Pulido, MD The Journal of Thoracic and Cardiovascular Surgery

Cost, quality, and value in coronary artery bypass grafting

It's not “just a shunt” but sometimes it should be…

Controlled hyperkalemic reperfusion with magnesium rescues ischemic juvenile hearts by reducing calcium loading Hajime Imura, MD, Hua Lin, MSc, Elinor.

Mehrdad M. R. Amirhamzeh, MD, David A

Ashok Muniappan, MD The Journal of Thoracic and Cardiovascular Surgery

Acute hemodynamic effects of restrictive mitral annuloplasty in patients with end-stage heart failure: Analysis by pressure-volume relations Sven A.F.

Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment Juan A. Crestanello, MD.

Ischemic postconditioning promotes left ventricular functional recovery after cardioplegic arrest in an in vivo piglet model of global ischemia reperfusion.

Leora B. Balsam, MD, Abe DeAnda, MD

Niv Ad, MD, Lawrence M. Wei, MD

Daniel T. Engelman, MD, FACS, Michael J. Germain, MD

Fueling the heart: Shifting the myocardial metabolome by targeting endothelial autophagy Nicholas D. Andersen, MD The Journal of Thoracic and Cardiovascular.

A fate worse than death Jennifer S. Lawton, MD

Passing the torch The Journal of Thoracic and Cardiovascular Surgery

Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction

Shunt right or left? Decision 2016

The role of a defined protocol for cardiac risk assessment in decreasing perioperative myocardial infarction in vascular surgery T.J. Bunt, MD Journal.

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Hans-Joachim Schäfers, MD

First nights, the adrenal axis, and steroids

Evan Loh, MD, Edward B. Lankford, MD, PhD, David J

The origins of open heart surgery at the University of Minnesota 1951 to 1956 Richard A. DeWall, MD The Journal of Thoracic and Cardiovascular Surgery

Jeffrey H. Shuhaiber, MD, Jeff Moore, MS, David B. Dyke, MD

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

The future of cardiac surgery training: A survival guide

Apparently, size matters…in congenital heart disease and brain injury

Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain Subhasis.

A practical method of measuring oxygen consumption in children with complex mixing circulations by the use of thermodilution cardiac output studies Daryl.

“The more things change…”: The challenges ahead

Large clinical databases for the study of lung cancer: Making up for the failure of randomized trials Chi-Fu Jeffrey Yang, MD, Matthew G. Hartwig, MD,

Appropriate Use Criteria for coronary revascularization in patients with stable ischemic heart disease: What the surgeon needs to know Harold L. Lazar,

Toll-like receptor 4 inhibition attenuates ischemia-reperfusion injury in rats: Will it work in human beings? Chadrick E. Denlinger, MD The Journal.

First in line for robotic surgery: Would you want to know?

Should heart transplantation be considered as a treatment option for patients aged 70 years and older? Jeffrey A Morgan, MD, Ranjit John, MD, Donna M.

Ryan R. Davies, MD The Journal of Thoracic and Cardiovascular Surgery

Commentary: Just say NO

Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy Y.

Respect the aorta The Journal of Thoracic and Cardiovascular Surgery

Proactive or reactive? Best approach to limb ischemia in peripheral venoarterial extracorporeal life support Matthew C. Black, MD, Mark S. Slaughter,

Presentation transcript:

Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia Y.Joseph Woo, MD, Matthew D Taylor, BS, Jeffrey E Cohen, Vasant Jayasankar, MD, Lawrence T Bish, BS, Jeffrey Burdick, BS, Timothy J Pirolli, Mark F Berry, MD, Vivian Hsu, Todd Grand, BS The Journal of Thoracic and Cardiovascular Surgery Volume 127, Issue 5, Pages 1262-1269 (May 2004) DOI: 10.1016/j.jtcvs.2003.11.032

Figure 1 ATP levels measured bioluminescently in ischemic myocardium 10 minutes after the initiation of ischemia. Significantly higher levels of ATP were observed in ethyl pyruvate–treated hearts (n = 5) compared with controls (n = 5). The Journal of Thoracic and Cardiovascular Surgery 2004 127, 1262-1269DOI: (10.1016/j.jtcvs.2003.11.032)

Figure 2 Lipid peroxidation in myocardium following ischemia and reperfusion. Lipid peroxidation in remote nonischemic myocardium was equivalent between control (n = 6) and ethyl pyruvate (n = 6) hearts. Ischemia increased the level of lipid peroxidation in the control hearts. The administration of ethyl pyruvate decreased the level of lipid peroxidation in the ischemic myocardium when compared with control hearts. The Journal of Thoracic and Cardiovascular Surgery 2004 127, 1262-1269DOI: (10.1016/j.jtcvs.2003.11.032)

Figure 3 Myocardial infarction percentage measured by infarction area (IA)/area at risk (AAR) following ischemia and reperfusion. Significant differences in left ventricular infarction were observed between animals receiving ethyl pyruvate (n = 15) and the control group (n = 15). The Journal of Thoracic and Cardiovascular Surgery 2004 127, 1262-1269DOI: (10.1016/j.jtcvs.2003.11.032)

Figure 4 Composite representation of end-systolic pressure-volume relationships (ESPVR) in native animals (n = 15) and in control (n = 15) and ethyl pyruvate–treated (n = 15) animals following ischemia and reperfusion. For native animals, mean ± SEM slope, x-axis intercept (x-int), and correlation coefficient (r) were: 1.27 ± 0.12, 10.4 ± 2.0, and 0.97 ± 0.07, respectively. For control animals, the values were: slope = 0.59 ± 0.2, x-int = 9.9 ± 24.0, r = 0.68 ± 0.13; for ethyl pyruvate–treated animals, these values were: slope = 1.09 ± 0.22, x-int = −4.1 ± 19.9, r = 0.89 ± 0.03. Comparing the slopes of the control and ethyl pyruvate hearts demonstrates a statistically significant improvement in contractility with the administration of ethyl pyruvate (P = .02). Composite ESPVR for the native animals (n = 15) was 1.27 (end-systolic volume [ESV]-10.39), control (n = 15) was 0.59 (ESV-9.88), and ethyl pyruvate (n = 15) was 1.09 (ESV-4.06). Significant differences in the slope of the ESPVR were found between ethyl pyruvate and control animals. The Journal of Thoracic and Cardiovascular Surgery 2004 127, 1262-1269DOI: (10.1016/j.jtcvs.2003.11.032)

The Journal of Thoracic and Cardiovascular Surgery 2004 127, 1262-1269DOI: (10.1016/j.jtcvs.2003.11.032)