Epithelial and Mesenchymal Contribution to the Niche: A Safeguard for Intestinal Stem Cell Homeostasis Nicholas R. Smith, Paige S. Davies, Alain D. Silk,

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Epithelial and Mesenchymal Contribution to the Niche: A Safeguard for Intestinal Stem Cell Homeostasis Nicholas R. Smith, Paige S. Davies, Alain D. Silk, Melissa H. Wong Gastroenterology Volume 143, Issue 6, Pages 1426-1430 (December 2012) DOI: 10.1053/j.gastro.2012.10.024 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 Comparison of in vivo (left) and in vitro (right) signaling support to the ISC. Signaling networks between the PC and stem cell seem to be broadly conserved. However, disruption of one element of a single pathway highlights the important compensation wired into the system where in vivo environments can rely on mesenchymal cells to maintain signaling homeostasis. Wnt, Notch, and EGF signaling pathways are key players in the balance between stem cell maintenance and differentiation. Gastroenterology 2012 143, 1426-1430DOI: (10.1053/j.gastro.2012.10.024) Copyright © 2012 AGA Institute Terms and Conditions