Prognostic evaluation based on a new TNM staging system proposed by the International Association for the Study of Lung Cancer for resected non–small.

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Prognostic evaluation based on a new TNM staging system proposed by the International Association for the Study of Lung Cancer for resected non–small cell lung cancers Takayuki Fukui, MD, Shoichi Mori, MD, Shunzo Hatooka, MD, Masayuki Shinoda, MD, Tetsuya Mitsudomi, MD The Journal of Thoracic and Cardiovascular Surgery Volume 136, Issue 5, Pages 1343-1348 (November 2008) DOI: 10.1016/j.jtcvs.2007.12.085 Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 The stage grouping according to the proposed system by the IASLC.10 The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1343-1348DOI: (10.1016/j.jtcvs.2007.12.085) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Distribution of the patients according to the current and proposed new stage groupings. The proportion of patients with stage IIA disease increased remarkably because they were reclassified from current stages IB and IIB. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1343-1348DOI: (10.1016/j.jtcvs.2007.12.085) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Survival curves for patient subgroups stratified according to stage groupings. The 5-year survival rate and the number of patients in each subgroup are indicated. A, With regard to the current staging system, no survival difference was observed between patients with stage IB and IIA disease (P = .54). B, With regard to the proposed system, the survival curves showed significant stepwise deterioration as the numbers increased, except for patients with stage IV tumors. There was a difference in the prognoses of patients with stage IB and IIA disease, although this was not statistically significant (P = .09). The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1343-1348DOI: (10.1016/j.jtcvs.2007.12.085) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Survival curves for patient subgroups stratified according to T descriptors. The 5-year survival rate and the number of patients in each subgroup are indicated. A, With regard to the current staging system, the survival curves showed significant stepwise deterioration as the numbers increased. B, For the proposed system, there was no significant prognostic difference between the new T1a and T1b stages (P = .35). The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1343-1348DOI: (10.1016/j.jtcvs.2007.12.085) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Survival curves for patient subgroups stratified according to N descriptors. The survival curves showed significant stepwise deterioration as the numbers increased. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1343-1348DOI: (10.1016/j.jtcvs.2007.12.085) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions