Chapter 10 Immune system

1. Components 1)  Cells

① Lymphocyte: a. T-lymphocytes: cytotoxic T cell: Tc C- kill the tumor cell, virus infective cell and foreign cell helper T cell: Th C- promotes activity of BLC and Tc C suppressor T cell: Ts C –regulate the function of BLC and TC b. B-lymphocytes: become into plasma cell c. NK cell: counteract virus infective cell and tumor cell

②Plasma cell ③antigen presenting cell: a. dendritic cell: Blood DC Langerhans cell interstitial cell veiled cell interdigitating cell b.macrophage: Mononuclear phagocytic system

④other cells: granulated cell mast cell blood platelet blood-borne stem cell *Function: i.      immunologic defence function ii.     immune surveillance function iii.    immune homeostasis

2)     Lymphoid tissue ---reticular T: reticular cell: stellate-shaped with processes to form network reticular fiber ---lymphocytes, macrophage, plasma cell mast cell

a. Diffuse LT: no clear boundary mainly consists of TLC postcapillary venules: -high endothelial venules -opening for LC enter LT from blood

b. Lymphoid nodule: spherical or ovoid have clear boundaries mainly composed of BLC germinal center: stained pale *primary LN → secondary LN

3) Lymphoid organs Central lymphoid organs: thymus, bone marrow developed earlier blood-borne stem cell comes from yolk sac microenvironment → proliferation promoting send LC to PLO and LT two weeks before borne

b. Peripheral lymphoid organs: lymph node, spleen and palatine tonsil developed later LC come from CLO cell proliferation need antigen stimulating - antigen dependent place for immune reactions

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