Volume growth of abdominal aortic aneurysms correlates with baseline volume and increasing finite element analysis-derived rupture risk Moritz Lindquist.

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Presentation transcript:

Volume growth of abdominal aortic aneurysms correlates with baseline volume and increasing finite element analysis-derived rupture risk Moritz Lindquist Liljeqvist, Rebecka Hultgren, MD, PhD, T. Christian Gasser, PhD, Joy Roy, MD, PhD Journal of Vascular Surgery Volume 63, Issue 6, Pages 1434-1442.e3 (June 2016) DOI: 10.1016/j.jvs.2015.11.051 Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 1 Meshed and analyzed finite element model of an abdominal aortic aneurysm (AAA). The red areas represent high estimated local ratios between wall stress and wall strength. Journal of Vascular Surgery 2016 63, 1434-1442.e3DOI: (10.1016/j.jvs.2015.11.051) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 2 A, Absolute and relative diameter growth rates plotted against baseline diameter. B, Absolute and relative volume growth rates plotted against baseline volume. Correlation was determined by Spearman rank correlation coefficient. Journal of Vascular Surgery 2016 63, 1434-1442.e3DOI: (10.1016/j.jvs.2015.11.051) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 3 Receiver operating characteristic (ROC) curve analysis of the ability of a baseline measurement to predict subsequent diameter and volume growth. Sensitivity was plotted against 100% - specificity in percentages. Baseline diameter is tested as a predictor of (A) absolute and (C) relative diameter growth. Baseline volume is tested as a predictor of (B) absolute and (D) relative volume growth. Journal of Vascular Surgery 2016 63, 1434-1442.e3DOI: (10.1016/j.jvs.2015.11.051) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 4 Diameter and volume growth plotted against peak wall stress (PWS) and peak wall rupture index (PWRI) change rates. Significant absolute diameter growth plotted against (A) PWS and (C) PWRI. Significant absolute volume growth plotted against (B) PWS and (D) PWRI. Correlations were determined with Spearman rank correlation coefficient and compared according to the method described by Zou,21 in which a confidence interval (CI) larger than 0 indicates a significantly stronger correlation. Journal of Vascular Surgery 2016 63, 1434-1442.e3DOI: (10.1016/j.jvs.2015.11.051) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 1 (online only) Patient selection process. AAA, Abdominal aortic aneurysm; CTA, computed tomography angiography. Journal of Vascular Surgery 2016 63, 1434-1442.e3DOI: (10.1016/j.jvs.2015.11.051) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 2 (online only) Correlation between abdominal aortic aneurysm (AAA) diameter and volume. A, Baseline volume plotted against baseline diameter. B, Volume growth rate plotted against diameter growth rate. Correlation was determined with the Spearman rank correlation coefficient. Journal of Vascular Surgery 2016 63, 1434-1442.e3DOI: (10.1016/j.jvs.2015.11.051) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 3 (online only) Baseline diameter and volume plotted against baseline wall stress and rupture index. Correlations were determined with the Spearman rank correlation coefficient and were compared according to the method described by Zou,21 in which a confidence interval (CI) larger than 0 indicates a significantly stronger correlation. PWRI, Peak wall rupture index; PWS, peak wall stress. Journal of Vascular Surgery 2016 63, 1434-1442.e3DOI: (10.1016/j.jvs.2015.11.051) Copyright © 2016 Society for Vascular Surgery Terms and Conditions