Philippe Dekleva and Scott Noblitt MicroChemica, LLC Fort Collins, CO

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Presentation transcript:

Rapid and Inexpensive Alternative for Ion Analysis: Online Microchip Electrophoresis Philippe Dekleva and Scott Noblitt MicroChemica, LLC Fort Collins, CO March 21, 2016 Grant award: 2R44ES017200-02A1 Contact: pdekleva@microchemica.com CONFIDENTIAL © Copyright 2016 MicroChemica

CONFIDENTIAL © Copyright 2016 MicroChemica Overview Problem Ionic contaminants in the environment Perchlorate, selenium, sulfate, metals, etc Real-time monitoring difficult Ion Chromatography (IC): expensive, online difficult, solution volumes Ion-selective electrodes (ISE): limited analytes, calibration drift Solution Microfluidic chemical separation Analysis times ≅ 1 min Low volumes (100 mL = weeks of operation) Contact conductivity detection Detection limits typically ≅ 10 ppb (lower possible) Can measure species that don’t absorb light CONFIDENTIAL © Copyright 2016 MicroChemica

CONFIDENTIAL © Copyright 2016 MicroChemica Technology Microchip electrophoresis Miniaturized separation and analysis Measures ionic (charged) species Sample are solutions (water, ethanol, etc) or dissolved in liquids Multiple species: ppb sensitivity & within minutes Result appears similar to chromatography CONFIDENTIAL © Copyright 2016 MicroChemica

CONFIDENTIAL © Copyright 2016 MicroChemica Novelty & Benefits Long-term operation (unattended weeks-months) Unique for a microfluidic or electrophoresis system Robust against insolubles and air bubbles in sample Speed and performance ~1 min for ppb-level measurements Precision values as good as 0.5% Can sacrifice speed for improved sensitivity & precision Cost ($20-50k) Lower cost than IC equivalent Both capital and consumables Small footprint Chip = 1×3”, detector & power supply ≅ shoebox size CONFIDENTIAL © Copyright 2016 MicroChemica

CONFIDENTIAL © Copyright 2016 MicroChemica Details Status Currently: benchtop format In development: online, real-time operation for field analyses Example targets: sulfate, nitrate, selenate, perchlorate, fluoride, acetate, ammonium, lithium, sodium, potassium, calcium, magnesium, or barium Limitations Target species must be charged (ion) Operating temperature < 50 °C Detection limit hindered by solution conductivity < 1 ppb in distilled water 1-40 ppb in tap water ~1 ppm in sea water CONFIDENTIAL © Copyright 2016 MicroChemica

CONFIDENTIAL © Copyright 2016 MicroChemica Applications Aerosol composition Sulfate in ethanol Perchlorate remediation Others upon request CONFIDENTIAL © Copyright 2016 MicroChemica

CONFIDENTIAL © Copyright 2016 MicroChemica References Grants NIH: 2R44ES017200-02A1 EPA: EPD15052 Patents Non-Fluidic Microdetection Device and Uses Thereof United States 11/932977 Microfluidic Interface for a Microchip United States 61/338971 Fluidic and Electrical Interface for Microfluidic Chips United States 13/677036 Publications On-Line Monitoring of Chloride and Sulfate in the Steam Cycle with a New Analytical Technique, Power Plant Chemistry, January 2013 CONFIDENTIAL © Copyright 2016 MicroChemica

CONFIDENTIAL © Copyright 2016 MicroChemica Thoughts & Comments Contact us to learn more about this exciting technology MicroChemica, LLC 3185-A Rampart Rd, Fort Collins, CO 80523 Phone 1 (970) 581-1857 pdekleva@microchemica.com CONFIDENTIAL © Copyright 2016 MicroChemica