Robert Zweigerdt, Ina Gruh, Ulrich Martin Cell Stem Cell

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Presentation transcript:

Your Heart on a Chip: iPSC-Based Modeling of Barth-Syndrome-Associated Cardiomyopathy Robert Zweigerdt, Ina Gruh, Ulrich Martin Cell Stem Cell Volume 15, Issue 1, Pages 9-11 (July 2014) DOI: 10.1016/j.stem.2014.06.015 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Modeling Barth Syndrome with Disease-Specific Induced Pluripotent Stem Cells iPSCs are generated from patients suffering from Barth syndrome. Additionally, disease-specific mutations are introduced into wild-type iPSC lines enabling direct comparison with isogenic controls. iPSC-derived cardiomyocytes are applied in a “heart-on-chip” assay to model the pathophysiology in vitro to investigate the underlying mechanism of Barth syndrome and to evaluate potential therapies. Cell Stem Cell 2014 15, 9-11DOI: (10.1016/j.stem.2014.06.015) Copyright © 2014 Elsevier Inc. Terms and Conditions