Figure 1 PCI strategies in patients with STEMI and multivessel disease Figure 1 | PCI strategies in patients with STEMI and multivessel disease. In patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease, primary percutaneous coronary intervention (PCI) for the culprit lesion is followed by evaluation of the severity of nonculprit lesions with the use of either visual estimation only or with additional fractional flow reserve (FFR) measurement during angiography. Treatment options for clinically significant nonculprit lesions include: multivessel primary PCI at the time of the index procedure, planned staged PCI either early (during the initial hospitalization) or late (after discharge), staged PCI if evidence exists of ischaemia on routine noninvasive stress testing, or optimal medical therapy alone. In case of a conservative approach with medical therapy only, the patient has to be re-evaluated when clinical symptoms reoccur. Vogel, B. et al. (2017) Reperfusion strategies in acute myocardial infarction and multivessel disease Nat. Rev. Cardiol. doi:10.1038/nrcardio.2017.88