Fast-Growing Large Cell Neuroendocrine Carcinoma of Mediastinum

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Fast-Growing Large Cell Neuroendocrine Carcinoma of Mediastinum Olga Lukina, MD, Stanislav Gorbunkov, MD, Ivetta Dvorakovskaja, MD, PhD, Vladimir Varlamov, MD, PhD, Andrey Akopov, MD, PhD The Annals of Thoracic Surgery Volume 91, Issue 5, Pages 1618-1620 (May 2011) DOI: 10.1016/j.athoracsur.2010.09.065 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Results of computed tomographic (CT) scans of the patient. (A, B) Preoperative CT scan shows multiple bullas in the upper lobes of both lungs. (C, D) The follow-up CT scan shows the giant tumor of the mediastinum with regions of necrosis, the anteriorly shifted heart, and spreading along the thoracic spine. The Annals of Thoracic Surgery 2011 91, 1618-1620DOI: (10.1016/j.athoracsur.2010.09.065) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Histologic picture showing large polygonal cells, with mitoses revealed. (Hematoxylin & eosin stain, ×20). (B) Immunohistochemistry for thyroid transcription factor-1 expression is positive (×20). The Annals of Thoracic Surgery 2011 91, 1618-1620DOI: (10.1016/j.athoracsur.2010.09.065) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions