Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth: Cohort study  Kristiane A. Engebretsen, MD, Peter Bager, MSc,

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Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth: Cohort study  Kristiane A. Engebretsen, MD, Peter Bager, MSc, PhD, Jan Wohlfahrt, MSc, DMSc, Lone Skov, MD, PhD, DMSc, Claus Zachariae, MD, DMSc, Anne-Marie Nybo Andersen, MD, PhD, Mads Melbye, MD, PhD, DMSc, Jacob P. Thyssen, MD, PhD, DMSc  Journal of Allergy and Clinical Immunology  Volume 139, Issue 5, Pages 1568-1574.e1 (May 2017) DOI: 10.1016/j.jaci.2016.11.021 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Domestic water hardness (°dH) in Denmark (2010). The map also shows the borders between Denmark's 98 municipalities (1°dH = 17.85 mg/L). Source: GEUS. Journal of Allergy and Clinical Immunology 2017 139, 1568-1574.e1DOI: (10.1016/j.jaci.2016.11.021) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Prevalence of AD (as a percentage) within the first 18 months of life according to domestic water hardness in the municipality of birth. Each data point represents the prevalence of AD among children born in one municipality or several municipalities with the same degree of domestic water hardness (within 1 decimal of °dH; 1°dH = 17.85 mg/L). Journal of Allergy and Clinical Immunology 2017 139, 1568-1574.e1DOI: (10.1016/j.jaci.2016.11.021) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Prevalence of AD (as a percentage) within the first 18 months of life according to week of birth. Journal of Allergy and Clinical Immunology 2017 139, 1568-1574.e1DOI: (10.1016/j.jaci.2016.11.021) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions