Scott D. Gitlin, MD, Michael Deeb, MD, Christopher Yann, BS, Alvin H

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Presentation transcript:

Intraoperative monitoring of danaparoid sodium anticoagulation during cardiovascular operations Scott D. Gitlin, MD, Michael Deeb, MD, Christopher Yann, BS, Alvin H. Schmaier, MD Journal of Vascular Surgery Volume 27, Issue 3, Pages 568-575 (March 1998) DOI: 10.1016/S0741-5214(98)70336-2 Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Effect of danaparoid sodium (Orgaran) on activated clotting time (ACT). A, Celite ACT with variable concentrations of danaparoid sodium. B, Kaolin ACT with 10 U/ml aprotinin and variable concentrations of danaparoid sodium. C, Kaolin ACT with 50 U/ml aprotinin and variable concentrations of danaparoid sodium. The points on the curve represent individual determinations at each concentration of danaparoid sodium. Journal of Vascular Surgery 1998 27, 568-575DOI: (10.1016/S0741-5214(98)70336-2) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 A, Effect of aprotinin and danaparoid sodium (Orgaran) on APTT. Boxes, APTT obtained in the absence of aprotinin; circles, APTT obtained in the presence of 50 U/ml aprotinin. The points on the curves represent the mean of similar duplicates. B, Concentration-dependent inhibition of bovine factor Xa activity with increased concentrations of danaparoid sodium (0.2 to 1.0 U/ml). The data are mean value ± SEM of six experiments. Samples that do not show SEM bars were too small to depict. Journal of Vascular Surgery 1998 27, 568-575DOI: (10.1016/S0741-5214(98)70336-2) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Intraoperative monitoring of ACT, APTT, and anti-factor Xa assays. A, Intraoperative ACT. B, Intraoperative APTT; values shown at 100 seconds actually represent values greater than 100 seconds. C, Intraoperative anti-factor Xa activity; values shown at 1 U/ml actually represent values greater than 1 U/ml. Values plotted for ACT represent single determinations. Values plotted for the APTT and anti-factor Xa assays represent means of similar duplicates. Journal of Vascular Surgery 1998 27, 568-575DOI: (10.1016/S0741-5214(98)70336-2) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions