Volume 67, Issue 5, Pages (May 2005)

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Presentation transcript:

Volume 67, Issue 5, Pages 1812-1820 (May 2005) Antibody blockade of TNF-α reduces inflammation and scarring in experimental crescentic glomerulonephritis Sarah B. Khan, H. Terence Cook, Gurjeet Bhangal, Jennifer Smith, Frederick W.K. Tam, Charles D. Pusey Kidney International Volume 67, Issue 5, Pages 1812-1820 (May 2005) DOI: 10.1111/j.1523-1755.2005.00279.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Experiment 2. Renal function and percentage crescents in individual rats treated with anti-tumor necrosis factor-α (TNF-α) monoclonal antibody from day 0 or day 4 until day 14. (A) Serum creatinine was lower in animals treated from either day 0 (*P < 0.05) or from day 4 (*P < 0.05) compared with controls. (B) Percentage of crescents was lower in animals treated from either day 0 (**P < 0.01) or day 4 (**P < 0.01) compared with controls. Treatment began at day 0 (▴), day 4 (▾), and control (▪). Kidney International 2005 67, 1812-1820DOI: (10.1111/j.1523-1755.2005.00279.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Experiment 3. Renal function in rats treated with anti-tumor necrosis factor-α (TNF-α) monoclonal antibody from day 4 until day 28. (A) Urinary protein to creatinine ratio was lower in animals treated from day 4 until day 28, at day 14 (**P < 0.01) compared with controls. (B) Serum creatinine was lower in animals treated from day 4 until day 28, at day 14 (**P < 0.01) and day 28 (***P < 0.001) compared with controls. Anti-TNF-α monoclonal antibody (▴) and control (▪). Kidney International 2005 67, 1812-1820DOI: (10.1111/j.1523-1755.2005.00279.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Experiment 3. Histology of kidney sections from rats treated with anti-tumor necrosis factor-α (TNF-α) monoclonal antibody from day 4 until day 28. (A) Histology from a control animal showing marked glomerular scarring with fibrous crescents, tubulointerstitial scarring with tubular atrophy, and tubulointerstitial inflammation (hematoxylin and eosin ×10). (B) Histology from a treated animal showing reduced glomerular and tubulointerstitial scarring, less tubular atrophy, and reduced interstitial inflammation compared with control (hematoxylin and eosin ×10). Kidney International 2005 67, 1812-1820DOI: (10.1111/j.1523-1755.2005.00279.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 4 Experiment 3. Immunohistochemistry for type IV collagen in kidneys from rats treated with anti-tumor necrosis factor-α (TNF-α) monoclonal antibody from day 4 until day 28. (A) Cortical type IV collagen immunohistochemistry from a control animal showing marked deposition (×20). (B) Cortical type IV collagen immunohistochemistry from an anti-TNF-α monoclonal antibody–treated animal showing reduced deposition compared with control (×20). Kidney International 2005 67, 1812-1820DOI: (10.1111/j.1523-1755.2005.00279.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 5 Experiment 4. Renal function in rats treated with anti-tumor necrosis factor-α (TNF-α) monoclonal antibody from day 14 until day 28. Serum creatinine was lower in treated animals at day 28 (*P < 0.05) compared with controls. Anti-TNF-α monoclonal antibody (▴) and control (▪). Kidney International 2005 67, 1812-1820DOI: (10.1111/j.1523-1755.2005.00279.x) Copyright © 2005 International Society of Nephrology Terms and Conditions