A L L degradation score Elastin 4 3 2 L L 1 Sham P rTM B L L

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A L L degradation score Elastin 4 3 2 L L 1 Sham P rTM B L L SMC content score 4 3 2 1 L L Sham P rTM SUPPLEMENTARY FIGURE 5. Treatment with rTMD123 preserves elastin integrity and SMCs in the aortic wall 28 days after AAA induction. A, medial elastin degradation (n=6). Elastin degradation grading scales (4 grades) by VVG staining are indicated in right panels (Blue arrows indicating disrupted elastic lamella). B, SMC content (n=6). SMC content grading scales (4 grades) by α-SMA staining are indicated in right panels. (P=AAA-PBS, rTM=AAA-rTM. **P<0.01, ***P<0.001 compared with sham. #P<0.05 compared with AAA-PBS. L indicates lumen. All scale bars represent 50 μm.)