Regulating Cancer Stem Cells the miR Way

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Regulating Cancer Stem Cells the miR Way Marcus E. Peter Cell Stem Cell Volume 6, Issue 1, Pages 4-6 (January 2010) DOI: 10.1016/j.stem.2009.12.006 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Network of miRNAs Regulating EMT and Stemness Three miRNAs/miRNA clusters (shown in black) regulate expression of stem cell factors and of ZEB1 (miRNA targets are shown in red). ZEB1 is a central regulator functionally connecting EMT with stem cell maintenance because of its ability to bind to E-boxes in the promoters of E-cadherin and all three miRNA gene clusters. Cell Stem Cell 2010 6, 4-6DOI: (10.1016/j.stem.2009.12.006) Copyright © 2010 Elsevier Inc. Terms and Conditions