Maria S. Soengas, E. Elizabeth Patton Cell Stem Cell

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Presentation transcript:

Location, Location, Location: Spatio-Temporal Cues That Define the Cell of Origin in Melanoma Maria S. Soengas, E. Elizabeth Patton Cell Stem Cell Volume 21, Issue 5, Pages 559-561 (November 2017) DOI: 10.1016/j.stem.2017.10.009 Copyright © 2017 Terms and Conditions

Figure 1 New Fluorescent Reporters for In Vivo Tracing of the Melanocytic Lineage Provide New Insights on the Cell of Origin of Melanoma Differential outcome of two characteristic melanoma-associated genetic alterations (activation of oncogenic BrafV600E and Pten loss) depends on the anatomical location (i.e., back versus tail skin) as reported by Köhler et al., or microenvironmental conditions related to UV irradiation as described by Moon et al. MCSC, melanoma cancer stem cell. Cell Stem Cell 2017 21, 559-561DOI: (10.1016/j.stem.2017.10.009) Copyright © 2017 Terms and Conditions