Microtubule Stabilization: Formins Assert Their Independence Aaron D. DeWard, Arthur S. Alberts  Current Biology  Volume 18, Issue 14, Pages R605-R608 (July 2008) DOI: 10.1016/j.cub.2008.06.001 Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 1 Formins mediate actin and microtubule cytoskeleton dynamics. (A) Schematic representation of mDia formin domains. (B) mDia formins nucleate and processively elongate F-actin by promoting the addition of actin monomers to the barbed (+) end. (C) A potential mode of microtubule stabilization by mDia2 binding to the sides of microtubules to mediate stabilization. (D) A mode of microtubule stabilization by mDia2 associating with microtubule-tip-binding proteins APC and EB1 in addition to protecting microtubules from disassembly. Current Biology 2008 18, R605-R608DOI: (10.1016/j.cub.2008.06.001) Copyright © 2008 Elsevier Ltd Terms and Conditions