Preoperative Standard Oral Nutrition Supplements vs Immunonutrition: Results of a Systematic Review and Meta-Analysis Refaat A. Hegazi, MD, PhD, MPH,

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Preoperative Standard Oral Nutrition Supplements vs Immunonutrition: Results of a Systematic Review and Meta-Analysis Refaat A. Hegazi, MD, PhD, MPH, MS, Deborah S. Hustead, PhD, David C. Evans, MD, FACS Journal of the American College of Surgeons Volume 219, Issue 5, Pages 1078-1087 (November 2014) DOI: 10.1016/j.jamcollsurg.2014.06.016 Copyright © 2014 American College of Surgeons Terms and Conditions

Figure 1 Preferred Reporting of Systematic Reviews and Meta-Analyses statement describing the identification, inclusion, and exclusion of randomized controlled trials evaluating the effect of preoperative immunonutrition on postoperative clinical outcomes compared with standard oral nutrition supplements and no supplements. Journal of the American College of Surgeons 2014 219, 1078-1087DOI: (10.1016/j.jamcollsurg.2014.06.016) Copyright © 2014 American College of Surgeons Terms and Conditions

Figure 2 Forest plot results of meta-analysis of preoperative immunonutrition (IN) vs standard oral nutrition supplements (ONS). (A) Preoperative immunonutrition (IN) vs standard oral nutrition supplements (ONS) on wound infection using random effects model. (B) Preoperative IN vs standard ONS on infectious complications using random effects model. (C) Preoperative IN vs standard ONS on noninfectious complications using random effects model. (D) Preoperative IN vs standard ONS on length of stay using random effects model. Journal of the American College of Surgeons 2014 219, 1078-1087DOI: (10.1016/j.jamcollsurg.2014.06.016) Copyright © 2014 American College of Surgeons Terms and Conditions

Figure 3 Forest plot results of meta-analysis of preoperative immunonutrition (IN) vs regular diet without supplements. (A) Preoperative immunonutrition (IN) vs no supplements (No Supp) on wound infection using random effects model. (B) Preoperative IN vs No Supp on infectious complications using random effects model. (C) Preoperative IN vs No Supp on noninfectious complications using random effects model. (D) Preoperative IN vs No Supp on length of stay using random effects model. Journal of the American College of Surgeons 2014 219, 1078-1087DOI: (10.1016/j.jamcollsurg.2014.06.016) Copyright © 2014 American College of Surgeons Terms and Conditions