A Stumper: How Much Spent for How Much Prevention? From the Publishers of Consult Guys A Stumper: How Much Spent for How Much Prevention? COPYRIGHT © 2018, ALL RIGHTS RESERVED

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Today’s Stumper What health care product’s benefit was first reported in 1977?

Hints Annual sales of the product in 2014 were estimated at $1.15 billion. It is estimated that by 2025, annual sales will be $3.69 billion. It is most often used in the prevention of cardiovascular disease. There is no evidence that it has any effect on cardiovascular disease.

Fish Oil

Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet. 1979;2:433-5. [PMID: 89498].

Hemostatic function and platelet polyunsaturated fatty acids in Eskimos Eskimos have a bleeding tendency Eskimos had decreased platelet aggregation They have a low incidence of cardiovascular disease Their diet rich in fish oil may be the explanation Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet. 1979;2:433-5. [PMID: 89498].

2012: No cardiovascular benefit Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 2012;308:1024-33. [PMID: 22968891] doi:10.1001/2012.jama.11374

2018: Still no cardiovascular benefit Aung T, Halsey J, Kromhout D, Gerstein HC, Marchioli R, Tavazzi L, et al; Omega-3 Treatment Trialists’ Collaboration. Associations of omega-3 fatty acid supplement use with cardiovascular disease risks: meta-analysis of 10 trials involving 77 917 individuals. JAMA Cardiol. 2018;3:225-34. [PMID: 29387889] doi:10.1001/jamacardio.2017.5205

Asbell PA, Maguire MG, Pistilli M, Ying GS, Szczotka-Flynn LB, Hardten DR, et al; Dry Eye Assessment and Management Study Research Group. n-3 fatty acid supplementation for the treatment of dry eye disease. N Engl J Med. 2018;378:1681-90. [PMID: 29652551] doi:10.1056/NEJMoa170969

Fish Oil No Better Than Placebo Asbell PA, Maguire MG, Pistilli M, Ying GS, Szczotka-Flynn LB, Hardten DR, et al; Dry Eye Assessment and Management Study Research Group. n-3 fatty acid supplementation for the treatment of dry eye disease. N Engl J Med. 2018;378:1681-90. [PMID: 29652551] doi:10.1056/NEJMoa170969

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