Angiotensin II receptor type 1 is upregulated in atrial tissue of patients with rheumatic valvular disease with atrial fibrillation Hongliang Cong, MD,

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Presentation transcript:

Angiotensin II receptor type 1 is upregulated in atrial tissue of patients with rheumatic valvular disease with atrial fibrillation Hongliang Cong, MD, PhD, Ximing Li, MD, PhD, Lijun Ma, MD, Hua Jiang, MD, Yongmin Mao, Meilin Xu The Journal of Thoracic and Cardiovascular Surgery Volume 140, Issue 2, Pages 298-304 (August 2010) DOI: 10.1016/j.jtcvs.2009.10.035 Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Bar graph for Western blot analysis results. LA, Left atrium; RA, right atrium; AF, atrial fibrillation; SR, sinus rhythm; Ang II, angiotensin II; AT1, angiotensin II receptor type 1; AT2, angiotensin II receptor type 2. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 298-304DOI: (10.1016/j.jtcvs.2009.10.035) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Reverse transcription−polymerase chain reaction results. A and B, Left atrium; C and D, right atrium; 1 − 5, atrial fibrillation group; 6 − 10, sinus rhythm group. GAPDH, Glyceraldehyde-3-phosphate dehydrogenase; AT1, angiotensin II receptor type 1; AT2, angiotensin II receptor type 2. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 298-304DOI: (10.1016/j.jtcvs.2009.10.035) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Expression of angiotensin II receptor type 2 in the left or right atrial tissues of the atrial fibrillation (AF) or sinus rhythm (SR) groups. A, Right atrial tissue of the AF group; B, right atrial tissue of the SR group, group; C, left atrial tissue of the AF group; D, left atrial tissue of the SR group. (Original magnification 10 × 20.) The Journal of Thoracic and Cardiovascular Surgery 2010 140, 298-304DOI: (10.1016/j.jtcvs.2009.10.035) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Expression of angiotensin II receptor type 1 in left or right atrial tissues of the atrial fibrillation (AF) and sinus rhythm (SR) groups. A, Right atrial tissue of the AF group; B, right atrial tissue of the SR group; C, left atrial tissue of the AF group; D, left atrial tissue of the SR group. (Original magnification 10 × 20). Angiotensin II receptor type 1 is strongly expressed in left atria of the AF group. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 298-304DOI: (10.1016/j.jtcvs.2009.10.035) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 A, Protein expression of angiotensin II receptor type 2 (AT2) in the left (LA) or right atrial (RA) tissues of the atrial fibrillation (AF) or sinus rhythm (SR) groups. B, Protein expression of angiotensin II receptor type 1 (AT1) in the LA or RA tissues of the AF or SR groups. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 298-304DOI: (10.1016/j.jtcvs.2009.10.035) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions