Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial† A.J. Wikkelsø, H.M. Edwards, A. Afshari, J.

Slides:

Advertisements

Similar presentations

Chewing gum for the treatment of postoperative nausea and vomiting: a pilot randomized controlled trial J.N. Darvall, M Handscombe, K Leslie British.

Advertisements

Effect of high-dose preoperative methylprednisolone on recovery after total hip arthroplasty: a randomized, double-blind, placebo-controlled trial T.H.

Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis B.M. Mishriky, N.H. Waldron, A.S. Habib British.

Effect of ventilation on cerebral oxygenation in patients undergoing surgery in the beach chair position: a randomized controlled trial G.S. Murphy,

Efficacy and adverse effects of buprenorphine in acute pain management: systematic review and meta-analysis of randomised controlled trials L.D. White,

Xylometazoline pretreatment reduces nasotracheal intubation-related epistaxis in paediatric dental surgery Z.A. El-Seify, A.M. Khattab, A.A. Shaaban,

Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized,

Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol–remifentanil total i.v. anaesthesia with desflurane anaesthesia

Comparison of the laryngoscopy views with the size 1 Miller and Macintosh laryngoscope blades lifting the epiglottis or the base of the tongue in infants.

K. Richardson, D.Z.H. Levett, S. Jack, M.P.W. Grocott

K.-Y. Ho, W Tay, M.-C. Yeo, H Liu, S.-J. Yeo, S.-L. Chia, N.-N. Lo

Effect of combining tramadol and morphine in adult surgical patients: a systematic review and meta-analysis of randomized trials V. Martinez, L. Guichard,

Cost-effectiveness of a systematic e-assessed follow-up of postoperative recovery after day surgery: a multicentre randomized trial K. Dahlberg, A. Philipsson,

Gabapentin prophylaxis for postoperative nausea and vomiting in abdominal surgeries: a quantitative analysis of evidence from randomized controlled clinical.

Association between fibrinogen level and severity of postpartum haemorrhage: secondary analysis of a prospective trial M. Cortet, C. Deneux-Tharaux,

Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery:

Does the prophylactic administration of magnesium sulphate to patients undergoing thoracotomy prevent postoperative supraventricular arrhythmias? A randomized.

Randomized controlled trial of goal-directed haemodynamic treatment in patients with proximal femoral fracture E. Bartha, C. Arfwedson, A. Imnell, M.E.

Prospective, randomized, controlled trial of thoracic epidural or patient-controlled opiate analgesia on perioperative quality of life M. Ali, D.C. Winter,

Viscoelastometry guided fresh frozen plasma infusion for postpartum haemorrhage: OBS2, an observational study P.W. Collins, R. Cannings-John, D. Bruynseels,

M.S. Evans, C. Lysakowski, M.R. Tramèr British Journal of Anaesthesia

A different use of visual analytic techniques in anaesthetics

Randomised trial comparing forced-air warming to the upper or lower body to prevent hypothermia during thoracoscopic surgery in the lateral decubitus.

Preoperative supplementation with fibrinogen concentrate in cardiac surgery: A randomized controlled study A. Jeppsson, K. Waldén, C. Roman-Emanuel,

Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis J.R. Bellis, M. Pirmohamed, A.J. Nunn, Y.K. Loke,

M Ranucci, E Baryshnikova British Journal of Anaesthesia

Randomized clinical trial of dexketoprofen/tramadol 25 mg/75 mg in moderate-to-severe pain after total hip arthroplasty H.J. McQuay, R.A. Moore, A. Berta,

D.H.J. Davis, M. Oliver, A.J. Byrne British Journal of Anaesthesia

Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional.

H. J. Kim, H. -C. Lee, Y. S. Jung, J. Lee, J. J. Min, D. -M. Hong, E

I.V. paracetamol as an adjunct to patient-controlled epidural analgesia with levobupivacaine and fentanyl in labour: a randomized controlled study K.

Perioperative administration of fibrinogen does not increase adverse cardiac and thromboembolic events after cardiac surgery J. Fassl, G. Lurati Buse,

D. Fletcher, V. Martinez British Journal of Anaesthesia

Impact of balanced tetrastarch raw material on perioperative blood loss: a randomized double blind controlled trial† A Joosten, R Tircoveanu, S Arend,

Sugammadex rapidly reverses moderate rocuronium- or vecuronium-induced neuromuscular block during sevoflurane anaesthesia: a dose–response relationship

Systemic oxygen extraction during exercise at high altitude

Lung recruitment and positive airway pressure before extubation does not improve oxygenation in the post-anaesthesia care unit: a randomized clinical.

Recovery after total intravenous general anaesthesia or spinal anaesthesia for total knee arthroplasty: a randomized trial† A Harsten, H Kehlet, S Toksvig-Larsen

H Viitanen, P Annila British Journal of Anaesthesia

Differential modulation of interleukin‐6 and interleukin‐10 by diclofenac in patients undergoing major surgery A.M. Mahdy, H.F. Galley, M.A. Abdel‐Wahed,

K. S. Khaw, S. W. Y. Lee, W. D. Ngan Kee, L. W. Law, T. K. Lau, F. F

N. Curry, C. Rourke, R. Davenport, S. Beer, L. Pankhurst, A. Deary, H

Corrigendum British Journal of Anaesthesia

Effect of supervised aerobic exercise rehabilitation on physical fitness and quality-of-life in survivors of critical illness: an exploratory minimized.

Observational study of the success rates of intubation and failed intubation airway rescue techniques in 7256 attempted intubations of trauma patients.

Fibrinogen supplementation ex vivo increasesclot firmness comparable to platelet transfusion in thrombocytopenia† B. Schenk, A.K. Lindner, B. Treichl,

Rapid sequence induction and intubation with rocuronium–sugammadex compared with succinylcholine: a randomized trial M.K. Sørensen, C. Bretlau, M.R.

Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery C. Solomon,

Thoracic paravertebral blocks in abdominal surgery – a systematic review of randomized controlled trials K. El-Boghdadly, C. Madjdpour, K.J. Chin British.

Single-dose intravenous paracetamol or propacetamol for prevention or treatment of postoperative pain: a systematic review and meta-analysis E.D. McNicol,

Chewing gum for the treatment of postoperative nausea and vomiting: a pilot randomized controlled trial J.N. Darvall, M Handscombe, K Leslie British.

Efficacy of butylscopolamine for the treatment of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study

Methylnaltrexone to prevent intrathecal morphine-induced pruritus after Caesarean delivery: a multicentre, randomized clinical trial M. Paech, B. Sng,

Teamwork, communication, and anaesthetic assistance in Scotland

Postoperative analgesic effect of intravenous (i. v

R. Badenes, F. Bilotta British Journal of Anaesthesia

T. Greco, M. G. Calabrò, R. D. Covello, M. Greco, L. Pasin, A

Postoperative analgesia with parecoxib, acetaminophen, and the combination of both: a randomized, double-blind, placebo-controlled trial in patients undergoing.

A randomized trial of the effect of low dose epinephrine infusion in addition to tranexamic acid on blood loss during total hip arthroplasty Ø. Jans,

T. W. Jones, D. Houghton, S. Cassidy, G. A. MacGowan, M. I. Trenell, D

Fibrinogen plasma concentration before delivery is not associated with postpartum haemorrhage: a prospective observational study O. Karlsson, A. Jeppsson,

Regional anaesthesia to improve pain outcomes in paediatric surgical patients: a qualitative systematic review of randomized controlled trials S. Suresh,

Levosimendan pre-treatment improves outcomes in patients undergoing coronary artery bypass graft surgery† L. Tritapepe, V. De Santis, D. Vitale, F. Guarracino,

C.M. Chalmers, A.M. Bal British Journal of Anaesthesia

Association between day and time of admission to critical care and acute hospital outcome for unplanned admissions to adult general critical care units:

Wee L. , Barron J. , Toye R. British Journal of Anaesthesia

6% Hydroxyethyl starch (130/0

A randomized, triple-masked, active-controlled investigation of the relative effects of dose, concentration, and infusion rate for continuous popliteal-sciatic.

R.L. Johnson, E.K. Cannon, C.B. Mantilla, D.A. Cook

Anaesthetic drugs and survival: a Bayesian network meta-analysis of randomized trials in cardiac surgery G. Landoni, T. Greco, G. Biondi-Zoccai, C. Nigro.

Presentation transcript:

Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial† A.J. Wikkelsø, H.M. Edwards, A. Afshari, J. Stensballe, J. Langhoff-Roos, C. Albrechtsen, K. Ekelund, G. Hanke, E.L. Secher, H.F. Sharif, L.M. Pedersen, A. Troelstrup, J. Lauenborg, A.U. Mitchell, L. Fuhrmann, J. Svare, M.G. Madsen, B. Bødker, A.M. Møller British Journal of Anaesthesia Volume 114, Issue 4, Pages 623-633 (April 2015) DOI: 10.1093/bja/aeu444 Copyright © 2015 The Author(s) Terms and Conditions

Fig 1 Consort flow diagram. ITT, intention to treat. *The subject who received fibrinogen despite allocation to placebo was included in the per-protocol analysis as part of the fibrinogen group (analysed as treated). British Journal of Anaesthesia 2015 114, 623-633DOI: (10.1093/bja/aeu444) Copyright © 2015 The Author(s) Terms and Conditions

Fig 2 Mean fibrinogen concentrations in placebo and fibrinogen groups from baseline to 24 h after study drug administration, with whiskers indicating standard deviation. Mean difference of the fibrinogen concentration between the fibrinogen and placebo group is given below at each time point from baseline to 24 h after the study drug administration, with 95% confidence interval (CI) given in parenthesis and P-value. British Journal of Anaesthesia 2015 114, 623-633DOI: (10.1093/bja/aeu444) Copyright © 2015 The Author(s) Terms and Conditions