Figure 2 Switching of biologic agents and biosimilars Figure 2 | Switching of biologic agents and biosimilars. Switching is a decision by the treating physician to exchange one medicine for another. Currently, physicians often need to decide about switching from the innovator biologic agent to a biosimilar. In the future, they will need to also consider a switch in the opposite direction (reverse-switch), or from one biosimilar to another (cross-switch). Danese, S. et al. (2016) Biosimilars in IBD: from theory to practice Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2016.155