Age-related Epstein-Barr virus (EBV)–associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly.

Slides:

Advertisements

Similar presentations

Allogeneic stem cell transplantation for adult Philadelphia chromosome–negative acute lymphocytic leukemia: comparable survival rates but different risk.

Advertisements

Hairy Cell Leukemia Variant Has Similar Survival to Classical Disease Despite Poorer Responses to Initial Therapy: A 30-Year Experience from Memorial Sloan.

EBV-positive diffuse large B-cell lymphoma of the elderly by Chi Young Ok, Thomas G. Papathomas, L. Jeffrey Medeiros, and Ken H. Young Blood Volume 122(3):

Critical Reviews in Oncology / Hematology

The Prognostic Value Of Dynamic Monitoring C-Reactive Protein (CRP) Serum Levels In NK/T-Cell Lymphoma by Bing Bai, Qi-chun Cai, Xiao-Xiao Wang, Qingqing.

by Satoshi Takeuchi, and Stephen I. Katz

Elevated Serum CD44 Level Is Associated With Unfavorable Outcome in Non-Hodgkin's Lymphoma by Raija Ristamäki, Heikki Joensuu, Kimmo Lappalainen, Lasse.

Do HSCs divide asymmetrically?

by Robert A. Kyle, Morie A. Gertz, Philip R. Greipp, Thomas E

NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case.

The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma.

by Dai Chida, Osamu Miura, Akihiko Yoshimura, and Atsushi Miyajima

EBV DNA: a Hodgkin lymphoma biomarker?

by Leah J. Anderson, and Richard Longnecker

The Frequency of Immunoglobulin Heavy Chain Gene and T-Cell Receptor γ-Chain Gene Rearrangements and Epstein-Barr Virus in ALK+ and ALK− Anaplastic Large.

Deregulated expression of the Myc cellular oncogene drives development of mouse “Burkitt-like” lymphomas from naive B cells by Delin Zhu, Chen Feng Qi,

A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma Blood Volume 89(11): June 1, 1997 ©1997.

by Thomas S. Uldrick, and Richard F. Little

How I treat hairy cell leukemia

Cyclin D1-negative mantle cell lymphoma with cryptic t(12;14)(p13;q32) and cyclin D2 overexpression by Christian Herens, Frédéric Lambert, Leticia Quintanilla-Martinez,

Lytic Replication of Epstein-Barr Virus in the Peripheral Blood: Analysis of Viral Gene Expression in B Lymphocytes During Infectious Mononucleosis and.

Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response by Andreas Rosenwald, Eric Y. Chuang,

Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD by Kathrin Rieger, Christoph Loddenkemper, Jochem Maul, Thomas Fietz,

One giant leap for pediatric AMKL

Expression of the chemokine receptors CXCR4, CXCR5, and CCR7 in primary central nervous system lymphoma by Kristoph Jahnke, Sarah E. Coupland, Il-Kang.

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque by Ruth Seggewiss, Stefania Pittaluga,

by Petri Salven, Lasse Teerenhovi, and Heikki Joensuu

A population-based study of cardiac morbidity among Hodgkin lymphoma patients with preexisting heart disease by Sten Myrehaug, Melania Pintilie, Lingsong.

Fusion genes in cord blood

What is a true ALCL? by Wolfram Klapper Blood Volume 124(9):

Simultaneous Ex Vivo Expansion of Cytomegalovirus and Epstein-Barr Virus–Specific Cytotoxic T Lymphocytes Using B-Lymphoblastoid Cell Lines Expressing.

Relationship of p53, bcl-2, and Tumor Proliferation to Clinical Drug Resistance in Non-Hodgkin's Lymphomas by Wyndham H. Wilson, Julie Teruya-Feldstein,

Antigen Presenting Phenotype of Hodgkin Reed-Sternberg Cells: Analysis of the HLA Class I Processing Pathway and the Effects of Interleukin-10 on Epstein-Barr.

Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative.

Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen–specific CD8+ T-cell function in Hodgkin.

High-dose radioimmunotherapy versus conventional high-dose therapy and autologous hematopoietic stem cell transplantation for relapsed follicular non-Hodgkin.

by Douglas D. Ross, Judith E. Karp, Tar T. Chen, and L. Austin Doyle

by Dongmei Song, Xiaobing Ye, Honglei Xu, and Shu Fang Liu

CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not by Naoko Ishibe, Maher Albitar, Iman.

CD19-targeting liposomes containing imatinib efficiently kill Philadelphia chromosome–positive acute lymphoblastic leukemia cells by Masamitsu Harata,

by Sara Tedoldi, Jennifer C

by Monika Priwitzerova, Guangjun Nie, Alex D

Differential gene expression of central nervous system lymphoma

Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome.

Alicia K. Morgans, MD, Ran Reshef, MD, Donald E. Tsai, MD, PhD

Norovirus gastroenteritis causes severe and lethal complications after chemotherapy and hematopoietic stem cell transplantation by Stefan Schwartz, Maria.

The immunophenotype of 177 adults with acute myeloid leukemia: proposal of a prognostic score by Ollivier Legrand, Jean-Yves Perrot, Marion Baudard, Annie.

Tumor Necrosis Factor Receptor-Associated Factor 1 Is Overexpressed in Reed-Sternberg Cells of Hodgkin’s Disease and Epstein-Barr Virus-Transformed Lymphoid.

Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination by J. Tristan Dobson,

B lymphocytes: how they develop and function

Brenton T. Tan, Roger A. Warnke, Daniel A. Arber

Th17 immune microenvironment in Epstein-Barr virus–negative Hodgkin lymphoma: implications for immunotherapy by Amy S. Duffield, Maria Libera Ascierto,

Figure 2 Elevated antibody reactivities against myelin and Epstein-Barr virus (EBV) peptides in relapsing-remitting multiple sclerosis (RRMS) and higher.

OBP-401 labels lung cancer cells in Gelfoam histoculture.

Redefining the role of etoposide in first-line treatment of peripheral T-cell lymphoma by Young Ae Kim, Ja Min Byun, Keeho Park, Gi Hwan Bae, Dukhyoung.

Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS by Takeshi Sugio, Kohta Miyawaki, Koji Kato, Kensuke Sasaki, Kyohei Yamada,

BCR-ABL1 gene rearrangement as a subclonal change in ETV6-RUNX1–positive B-cell acute lymphoblastic leukemia by Karen A. Dun, Rob Vanhaeften, Tracey J.

Predicted number of joint bleeds according to factor activity level and age group for patients with hemophilia A or B based on a regression model. Predicted.

A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion by Christopher A. Miller, Christopher.

AIDS-related B-cell lymphoma (ARL): correlation of prognosis with differentiation profiles assessed by immunophenotyping by Christian Hoffmann, Markus.

Reverse transcriptase polymerase chain reaction (RT-PCR) analysis of EBNA1 promoter usage in Epstein-Barr virus (EBV) associated disorders. Reverse transcriptase.

Survival based on V gene mutation status and CD38 expression among B-CLL patients who stratify to the Rai intermediate risk category. Survival based on.

Time-dependent survival estimation in post–polycythemia vera myelofibrosis. Time-dependent survival estimation in post–polycythemia vera myelofibrosis.

IFN-γ-producing T-cells in SLE patients and healthy controls upon EBV antigen stimulation. IFN-γ-producing T-cells in SLE patients and healthy controls.

Activated T-cells in SLE patients and healthy controls upon EBV antigen stimulation. Activated T-cells in SLE patients and healthy controls upon EBV antigen.

Influence of ASGR2 expression on survival.

by Lapo Alinari, and Kristie A. Blum

Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy.

CD10−MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features by Kennosuke Karube, Ying Guo, Junji.

Cold agglutinin disease

Presentation transcript:

Age-related Epstein-Barr virus (EBV)–associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients by Naoko Asano, Kazuhito Yamamoto, Jun-Ichi Tamaru, Takashi Oyama, Fumihiro Ishida, Koichi Ohshima, Tadashi Yoshino, Naoya Nakamura, Shigeo Mori, Osamu Yoshie, Yoshie Shimoyama, Yasuo Morishima, Tomohiro Kinoshita, and Shigeo Nakamura Blood Volume 113(12):2629-2636 March 19, 2009 ©2009 by American Society of Hematology

Histopathologic profile of age-related EBVLPD Histopathologic profile of age-related EBVLPD. (A) Hodgkin and Reed-Sternberg (HRS)–like giant cells were frequently observed scattered among reactive cells. Histopathologic profile of age-related EBVLPD. (A) Hodgkin and Reed-Sternberg (HRS)–like giant cells were frequently observed scattered among reactive cells. These cells showed CD20 expression (B), in addition to positive signals for EBNA2 (C). Images were acquired using an Olympus AX80 microscope (Olympus, Tokyo, Japan) with a 100×/1.35 oil Iris lens (Olympus). Staining was with L26/CD20 and EBNA2 (Dako, Glostrup, Denmark). Images were captured with an Olympus DP70 camera and processed with Adobe Photoshop Elements, version 7 (Adobe Systems, San Jose, CA). Naoko Asano et al. Blood 2009;113:2629-2636 ©2009 by American Society of Hematology

Survival curves. Survival curves. (A) Survival curves for age-related EBVLPD and EBV-positive cHL patients. Age-related EBVLPD showed a poorer prognosis than EBV-positive cHL. (B) Survival curves of patients with age-related EBVLPD stratified according to IPI score. (C) Survival curves of patients with age-related EBVLPD stratified according to the prognostic score of age-related EBVLPD. (D) Survival curves of patients with EBV-positive cHL stratified according to the IPFP score. (E) Survival curves of patients with EBV-positive cHL stratified according to the prognostic score of age-related EBVLPD. Naoko Asano et al. Blood 2009;113:2629-2636 ©2009 by American Society of Hematology