The Path to Perdition Is Paved with Protons

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The Path to Perdition Is Paved with Protons Rachel Green, Jon R. Lorsch Cell Volume 110, Issue 6, Pages 665-668 (September 2002) DOI: 10.1016/S0092-8674(02)00965-0

Figure 1 Proposed Chemical Reaction Mechanism for Peptide Bond Formation Groups that must lose a proton are in red and those that must gain a proton are in blue. The P and A site tRNAs are on the left and right, respectively. The transition state analog used to locate the active site of the 50S subunit of the ribosome is boxed. Positions corresponding to the carbonyl oxygen and the nucleophilic amine are indicated with aqua and red arrows, respectively. Cell 2002 110, 665-668DOI: (10.1016/S0092-8674(02)00965-0)

Figure 2 View of the Active Site of the Ribosome Focusing on Nucleotides Proximal to the Bound Transition State Analog A2451 is in green and the A2450:C2063 base pair is in red. The purple strand is the TSA with the tetrahedral center in black. Note that the model of the 50S•TSA complex (PDB ID 1FFZ) is unrefined. The figure was made by Silke Dorner using the program Ribbons (M. Carson). Cell 2002 110, 665-668DOI: (10.1016/S0092-8674(02)00965-0)