Prior gastroscopy and mortality in patients with gastric cancer: a matched retrospective cohort study Wai K. Leung, MD, Hsiu J. Ho, PhD, Jaw-Town Lin,

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Prior gastroscopy and mortality in patients with gastric cancer: a matched retrospective cohort study Wai K. Leung, MD, Hsiu J. Ho, PhD, Jaw-Town Lin, MD, Ming-Shiang Wu, MD, Chun-Ying Wu, MD Gastrointestinal Endoscopy Volume 87, Issue 1, Pages 119-127.e3 (January 2018) DOI: 10.1016/j.gie.2017.06.013 Copyright © 2018 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 1 Flow diagram of patient selection.∗ A case could be excluded because of more than 1 criterion. Therefore, the total excluded cases in each step may outnumber the sum of case numbers excluded by individual criteria. <2 Y cohort: receiving endoscopy between 6 months and 2 years before the index date; 2-5 Y cohort: receiving endoscopy more than 2 years and less than or equal to 5 years before the index date; >5 Y cohort: never received endoscopy within the previous 5 years of the index date. GCA, gastric cancer; NHIRD, National Health Insurance Research Database. Gastrointestinal Endoscopy 2018 87, 119-127.e3DOI: (10.1016/j.gie.2017.06.013) Copyright © 2018 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 2 Cumulative incidences of all-cause mortality and gastric cancer–specific mortality in patients with gastric cancer who had prior gastroscopy at different time intervals. A, All-cause mortality. B, Gastric-cancer–specific mortality. Calculation and comparison of cumulative mortalities were conducted by using the Kaplan-Meier method (P < .001 for both all-cause and gastric cancer–specific mortalities when comparing <2 Y versus >5 Y and 2 to 5 Y versus >5 Y cohorts. P value was not significant when we compared <2 Y versus 2 to 5 Y cohorts). Gastrointestinal Endoscopy 2018 87, 119-127.e3DOI: (10.1016/j.gie.2017.06.013) Copyright © 2018 American Society for Gastrointestinal Endoscopy Terms and Conditions

Supplementary Figure 1 Cumulative incidences of mortality not related to gastric cancer in patients who had prior gastroscopies in different time frames. Gastrointestinal Endoscopy 2018 87, 119-127.e3DOI: (10.1016/j.gie.2017.06.013) Copyright © 2018 American Society for Gastrointestinal Endoscopy Terms and Conditions

Supplementary Figure 2 Cumulative incidences of all-cause mortality in patients according to different age groups. A, Patients younger than 65 years (log rank; P < .001). B, Patients aged from 65 to 80 years (log rank; P < .001). Gastrointestinal Endoscopy 2018 87, 119-127.e3DOI: (10.1016/j.gie.2017.06.013) Copyright © 2018 American Society for Gastrointestinal Endoscopy Terms and Conditions

Supplementary Figure 3 Cumulative incidences of all-cause mortality in patients with gastric cancer who had prior gastroscopies in different time frames up to 8 years. The original control cohort was further classified into a 6 to 8–year cohort (between 5 and 8 years) and a >8 years (no endoscopy in previous 8 years) cohort. The 4 groups were again matched in a 1:1:1:4 ratio as described previously (log-rank; P < .001). Gastrointestinal Endoscopy 2018 87, 119-127.e3DOI: (10.1016/j.gie.2017.06.013) Copyright © 2018 American Society for Gastrointestinal Endoscopy Terms and Conditions