Nat. Rev. Endocrinol. doi: /nrendo

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Nat. Rev. Endocrinol. doi:10.1038/nrendo.2016.84 Figure 1 Different chronic syndromes during long-term follow‑up of patients treated for pituitary tumours Figure 1 | Different chronic syndromes during long-term follow-up of patients treated for pituitary tumours. Pituitary insufficiency is a common feature in many patients treated for nonfunctioning macroadenomas, craniopharyngiomas, acromegaly or Cushing disease. Hypothalamic dysregulation is another common denominator in patients treated previously for large tumours with suprasellar extension and initial visual-field defects, and is induced by the tumour and/or the treatment modalities. In patients with previous excess of cortisol (Cushing disease) or growth hormone (GH) and insulin-like growth factor 1 (IGF-1; as in acromegaly), the irreversible effects of these hormones cause chronic multisystem morbidity, and in Cushing disease are also associated with death. *Most observations are obtained in nonfunctioning macroadenomas, but the same complications are likely to be present in other macroadenomas with visual-field defects Romijn, J. A. (2016) The chronic syndromes after previous treatment of pituitary tumours Nat. Rev. Endocrinol. doi:10.1038/nrendo.2016.84