Volume 21, Issue 9, Pages (September 2013)

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Presentation transcript:

Volume 21, Issue 9, Pages 1500-1508 (September 2013) Conformational States of Macromolecular Assemblies Explored by Integrative Structure Calculation Konstantinos Thalassinos, Arun Prasad Pandurangan, Min Xu, Frank Alber, Maya Topf Structure Volume 21, Issue 9, Pages 1500-1508 (September 2013) DOI: 10.1016/j.str.2013.08.006 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 Diverse Types of Information Calculated Based on Data from Various Techniques about a Dynamic Complex (A–C) Information based on MS techniques, including peptides indicating crosslinks, solvent exposure information from HDX-MS, and arrival time distributions from IM-MS that can be used to calculate CCSs (A), 3D density maps of two conformational states detected from cryo ET classifications (B), and atomic models of the complex resulting from X-ray crystallography, NMR spectroscopy, or structure prediction methods (C). (D) The information can be combined to provide pseudo-atomic models of the complex in multiple conformations. Structure 2013 21, 1500-1508DOI: (10.1016/j.str.2013.08.006) Copyright © 2013 Elsevier Ltd Terms and Conditions